H-Index
79
Scimago Lab
powered by Scopus
JCR
Clarivate
Analytics
15%
Acceptance
Rate
call: +1.631.470.9640
Mon-Fri 10 am - 2 pm EST

Logo



eISSN: 1643-3750

Get your full text copy in PDF

Bacterial adhesins and the role of sialic acid in bacterial adhesion.

Serhan Sakarya, Serkan Öncü

Med Sci Monit 2003; 9(3): RA76-82

ID: 4713


Bacterial infection, which basically starts when the microorganism binds to certain host cells, is a multi-factorial process that can be subdivided into distinct stages. To initiate infection, pathogens must first be able to colonize an appropriate host target tissue. Colonization begins
with attachment. The primary stage of infection is modulated by specific molecules on both the pathogens and the host cells. The bacterial factors are often called adhesins, and the host cell factors are receptors. The initial contact between adhesins and receptors always involves biophysical and biochemical interactions. Although adhesin proteins and bacterial lectins are the most common functional elements of adhesins, the carbohydrate content of receptors is
their most functional part. Blocking the primary stage of infection may be the most effective strategy to prevent bacterial infections. Although adhesin-based vaccine studies have been demonstrated to protect against infections, the large number of bacterial adhesin structures
would necessitate the development of a different vaccine for each bacteria. In contrast, most of the adhesin receptors on eukaryotic cells are rich in carbohydrates, and many of these carbohydrate
moieties are rich in sialic acid, although some of them are not well defined. Thus receptor carbohydrate moieties and their sialic acid content may be key targets in this strategy.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree