H-Index
75
Scimago Lab
powered by Scopus
JCR
Clarivate
Analytics
17%
Acceptance
Rate
call: +1.631.4701.9640
Mon-Fri 10 am - 2 pm EST

Logo



eISSN: 1643-3750

Get your full text copy in PDF

The efficacy of hydrotalcite compared with OTC famotidine in the on-demand treatment of gastroesophageal reflux disease: A non-inferiority trial

Jan W. Konturek, Manfred Beneke, Ralf Koppermann, Marianne Petersen-Braun, Ulrike Weingärtner

Med Sci Monit 2007; 13(1): CR44-49

ID: 470149


Background: Antacids and gastric acid inhibitors are effective in the self-treatment of gastroesophageal reflux disease (GERD). The aim was to investigate onset of action of the antacid hydrotalcite compared
with the OTC H2-receptor antagonist famotidine in patients suffering from heartburn.
Material/Methods: A total of 53 patients with endoscopically diagnosed GERD grade 0–1 took part in this open, randomized, parallel-group comparison trial: 26 patients received a single dose of 1000 mg hydrotalcite and 27 patients a single dose of 10 mg famotidine on the occasion of a symptomatic reflux
episode. Severity of heartburn and accompanying symptoms were documented on a four-point verbal rating scale (VRS) at baseline and up to four hours after intake. Onset and duration of action were defined by the number of patients experiencing improvement of heartburn from severe or
moderate to mild or none compared with baseline.
Results: Hydrotalcite was significantly superior (p

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree