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Background: Minimal access techniques have gained wide acceptance in surgicalpractice, but the role of laparoscopic pancreaticoduodenectomy is still controversial. Laparoscopic pancreaticoduodenectomyhas seldom been described. In this report, we assessed the feasibility and safety of laparoscopic pancreaticoduodenectomyfor ductal adenocarcinoma of the common bile duct. Case Report: According to imaging findings, a 71-year-oldChinese man was diagnosed with malignancy of the common bile duct, and successfully underwent laparoscopicpancreaticoduodenectomy in our center. The operation's safety, postoperative recovery, complications,oncological clearance, and short-term follow-up results of the patient are evaluated. No severe intraoperativeor postoperative complications were observed. The operation time was 390 minutes, and the blood losswas about 50 ml; the flatus, time to resume early activity and hospital stay were 3, 4, and 30 days respectively.The patient remained well at a follow-up of 6 months. Conclusions: Laparoscopic pancreaticoduodenectomycan be performed feasibly and safely by surgeons with advanced laparoscopic skills, and could be consideredfor the treatment of common bile duct tumors.