10 April 2006
Serum prolactin level in patients with multiple sclerosis: A case control study.
Mohammad H. Harirchian, Mohammad A. Sahraian, Afsaneh ShiraniMed Sci Monit 2006; 12(4): CR177-180 :: ID: 448906
Abstract
Background: Multiple sclerosis (MS) is the most common demyelinating disorderof the central nervous system and is considered to be multifactorial with an autoimmune component. Prolactin(PRL) is a neuroendocrine peptide with potent immunomodulatory properties. Hyperprolactinemia enhancesseveral autoimmune disorders and may play a role in the pathogenesis of MS. The aim of this study wasto compare serum PRL levels in MS patients with those of healthy controls. Material/Methods: There were43 patients with definite MS and 43 sex- and age-matched healthy controls. Conditions leading to a risein PRL, such as pregnancy, lactation, and specific underlying diseases and drugs, were excluded. PRLlevels were measured in fasting blood samples. For the MS group, disease duration and subtype, clinicalmanifestations, and expanded disability status scores (EDSS) were also recorded. Results: There wereno significant differences in serum PRL levels between the case and control groups in both women andmen (376.78+/-231.11 mIU/l in female patients with MS vs. 364.19+/-202.55 mIU/l in female controls, 266.00+/-200.83mIU/l in male patients with MS vs. 197.25+/-65.25 mIU/l in male controls). We also found no significantrelationship between PRL and disease activity, disease duration, and EDSS. Conclusions: Our findingsdo not support the hypothesis that MS patients are in a hyperprolactinemic state. However, further studiesin more homogenous MS subgroups are needed.
Keywords: Case-Control Studies, Hyperprolactinemia - complications, Models, Biological, Multiple Sclerosis - etiology, Multiple Sclerosis, Chronic Progressive - etiology, Multiple Sclerosis, Relapsing-Remitting - etiology, Prolactin - blood
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
06 Mar 2024 : Clinical Research
Prevalence and Variation of Medical Comorbidities in Oral Surgery Patients: A Retrospective Study at Jazan ...Med Sci Monit In Press; DOI: 10.12659/MSM.943884
08 Mar 2024 : Clinical Research
Evaluation of Foot Structure in Preschool Children Based on Body MassMed Sci Monit In Press; DOI: 10.12659/MSM.943765
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952