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Stjepan Mise, Ante Tonkic, Valdi Pesutic, Marija Tonkic, Sandro Mise, Vesna Capkun, Lovorka Batelja, Alenka Boban Blagaic, Neven Kokic, Ivan Zoricic, Davor Saifert, Tomislav Anic, Sven Seiwerth, Predrag Sikiric
Med Sci Monit 2006; 12(4): BR146-153
Background: Adaptive cytoprotection could be demonstrated in lesion attenuationwithin the whole gastrointestinal tract, in particular sequences, with onset and duration longer thanthe initial short-lasting period (i.e. one hour) defined by Robert in the stomach only. Material/Methods:Adaptive cytoprotection possibly appeared and lesions were attenuated when the stomach, duodenum or colon,in various combinations and sequences, were challenged with initial (mild) and/or final (strong) irritantsover a two-week period. Rats were challenged with the mild or strong irritants 25% or 96% ethanol intragastrically1 ml/rat (stomach) and cysteamine 40 mg or 400 mg/kg subcutaneously (duodenum), or intrarectally (colon).To postulate the prostaglandin relationship known in Robert's cytoprotection and adaptive cytoprotection,indomethacin (1 mg/kg subcutaneously) was given simultaneously with the second challenge. Results: Administeringthe mild and strong irritant protocols within the same part of the gastrointestinal tract, adaptive cytoprotectionpresents in the stomach (1 h to 14 days), duodenum (2 h to 14 days), but not in the colon. With theseprotocols applied to different parts of the gastrointestinal tract, adaptive cytoprotection cross-reactionwas evident in the stomach-duodenum, duodenum-stomach (1 h-14 days and 2 h-14 days), stomach-colon, andduodenum-colon (both 2-24 hours), but not in the colon-stomach or colon-duodenum. This protection wasfully antagonized with indomethacin. Conclusions: As observed for a day and even weeks, stomach-duodenum-colonadaptive cytoprotection is an important new defensive phenomenon.