01 February 2006
Pilot study of the G-protein beta3 subunit gene (C825T) polymorphism and clinical response to Olanzapine or Olanzapine-related weight gain in persons with schizophrenia.
Jeffrey R. Bishop, Vicki L. Ellingrod, Jessica Moline, Del MillerMed Sci Monit 2006; 12(2): BR47-50 :: ID: 445225
Abstract
Background: Despite advances in schizophrenia treatment, nearly 30% ofpatients do not respond to atypical antipsychotic agents, such as olanzapine. Furthermore, 30-60% ofpatients will gain significant weight during the course of olanzapine therapy. Little research has beendone to investigate the relationship between antipsychotic treatment outcomes and genetic variabilityin second messengers coupled to serotonin (5HT) receptors. The purpose of this investigation was examineassociations between the second messenger G-Protein Beta3 Subunit Gene (GNB3) C825T polymorphism andolanzapine response and weight gain treatment. Material/Methods: We conducted a pharmacogenetic associationstudy to examine GNB3 genotypes in relation to olanzapine clinical response (as measured by the BriefPsychiatric Rating Scale or Scale for the Assessment of Negative Symptoms) or weight gain. Subjects includedforty-two individuals meeting DSM-IV criteria for schizophrenia that started olanzapine, were titratedto a fixed dose for 6 weeks, and subsequently genotyped for this investigation. Results: No statisticallysignificant associations existed between our outcome variables and GNB3 genotypes. However we did observetrends suggesting a potential relationship between the TT genotype, response, and weight gain that warrantfurther investigation. Conclusions: Preliminary results showed no statistical relationship between theC825T polymorphism and olanzapine response or weight gain. Numerical differences in outcome measuresbetween the TT vs. CT/CC genotype groups indicate that G-protein second messenger systems variabilitycoupled to primary targets of atypical antipsychotics may relate to clinical outcomes in persons withschizophrenia and that future research in this area is warranted.
Keywords: Base Sequence, Antipsychotic Agents - therapeutic use, Benzodiazepines - therapeutic use, DNA - genetics, Heterotrimeric GTP-Binding Proteins - genetics, Obesity - pathology, Pilot Projects, Polymorphism, Single Nucleotide, Protein Subunits - genetics, Schizophrenia - genetics, Serotonin Uptake Inhibitors - therapeutic use, Weight Gain - genetics
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
18 Apr 2024 : Clinical Research
Comparative Analysis of Open and Closed Sphincterotomy for the Treatment of Chronic Anal Fissure: Safety an...Med Sci Monit In Press; DOI: 10.12659/MSM.944127
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952