H-Index
75
Scimago Lab
powered by Scopus
JCR
Clarivate
Analytics
21%
Acceptance
Rate
call: +1.631.470.9640
Mon-Fri 10 am - 2 pm EST

Logo



eISSN: 1643-3750

Get your full text copy in PDF

Dendritic and cancer cells in the breast tumors - an immunohistochemical study: short communication.

B Lewko, A Zółtowska, J Stepiński, A Roszkiewicz, G Moszkowska

Med Sci Monit 2000; 6(5): BR892-895

ID: 444897


Normal and dysplastic mammary glands express immunocompetent S-100 proteinpositive dendritic cells (DCs), which are located in a regular pattern, in the suprabasal cell layerof the ducts and alveolar nodules. The epithelial cells, however, are S-100 protein negative. Since somebreast cancers also express the S-100 protein, our aim was to check the diagnostic and prognostic valueof the S-100 protein distribution combined with the tumor grade and expression of synaptophysin (Syn),chromogranin A (Chg A), c-erbB-2 oncoprotein and p53 protein in infiltrating and metastatic breast tumors.Applying immunohistochemical methods, we show in paraffin- or frozen breast tissue sections that in somecases of the infiltrating breast carcinomas, S-100 protein positive cells do not appear, whereas in othercases, either S-100 protein positive DCs are closely associated with cancer cells, or the cancer cellsthemselves stain positive to S-100 protein. However, we found no correlation between the S-100 proteinexpression and other investigated parameters.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree