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Occupational bladder cancer: from cohort study to biologic molecular marker.

Kazumasa Matsumoto, Akira Irie, Takefumi Satoh, Hidetoshi Kuruma, Takashi Arakawa, Shiro Baba

Med Sci Monit 2005; 11(10): RA311-315

DOI: 10.12659/MSM.430336

Cancer prevention in people occupationally exposed to carcinogens thatcause bladder cancer has focused on early cancer detection by use of traditional screening methods includinghematuria testing, urinary cytology, and cystoscopy. However, these screening methods showed limitationsin terms of reducing mortality from bladder cancer. Currently, several molecular substances have shownpotential as screening markers for bladder cancer. This article reviews epidemiologic cohort studies,hematuria screening, and the biologic molecular markers for bladder cancer related to occupational carcinogenicity.Considering the long latency period, new cases of occupational bladder cancer have been expected to occurmore frequently. Because of recent advances in molecular techniques, biologic markers have a potentialrole in screening for and monitoring of occupational bladder cancers.

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