01 September 2005
Oxidative stress and histopathological changes in the heart following orallindane (gamma hexachlorohexane) administration in rats.
Roy Ananya, Sood Subeena, Dinda Amit Kumar, Das Taposh Kumar, Maulik Subir KumarMed Sci Monit 2005; 11(9): BR325-329 :: ID: 428443
Abstract
Background: Lindane is a persistent, bioaccumulative, and toxic organochlorineinsecticide. Human exposure to lindane (gamma hexachlorohexane) occurs via food and water. It is largelyknown to cause toxicity in various organs, such as the liver, brain, and testes. Appreciable amountsof lindane also accumulate in the heart. However, the effect of chronic lindane exposure on the heartis not well investigated. Material/Methods: The present study was designed to explore the effect of oraladministration of lindane (1.5 and 7 mg/kg/day for 21 days) on lipid peroxidation, endogenous antioxidants(GSH, SOD and catalase), and histopathological changes (light and electron microscopic studies) of rathearts. Results: Lipid peroxidation of the heart, as measured by thiobarbituric acid reactive substances,(TBARS) was increased, with a decrease in GSH level. An increase in SOD and catalase activities was observedin the 7-mg/kg/day dose of lindane. Interstitial edema in the myocardium was observed in both doses.Ultrastructural changes consisted of loss of integrity of the myofibrils, Z-band disruption, and mitochondrialdamage. Conclusions: This is the first study to report lindane-induced oxidative stress in the heart.Our observations have significant clinical relevance, as oxidative stress plays a key role in the pathogenesisand progression of major cardiovascular disorders.
Keywords: Lindane - toxicity, Thiobarbituric Acid Reactive Substances - metabolism, Superoxide Dismutase - metabolism, Rats, Wistar, Oxidative Stress - drug effects, Myocardium - ultrastructure, Microscopy, Electron, Lipid Peroxidation - drug effects, Antioxidants - metabolism, Insecticides - toxicity, Heart - drug effects, Glutathione - metabolism, Catalase - metabolism, Administration, Oral
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
05 Mar 2024 : Clinical Research
Role of Critical Shoulder Angle in Degenerative Type Rotator Cuff Tears: A Turkish Cohort StudyMed Sci Monit In Press; DOI: 10.12659/MSM.943703
06 Mar 2024 : Clinical Research
Comparison of Outcomes between Single-Level and Double-Level Corpectomy in Thoracolumbar Reconstruction: A ...Med Sci Monit In Press; DOI: 10.12659/MSM.943797
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
10 Apr 2024 : Clinical Research
Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Dep...Med Sci Monit In Press; DOI: 10.12659/MSM.942612
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952