Scimago Lab
powered by Scopus
call: +1.631.470.9640
Mon-Fri 10 am - 2 pm EST


Medical Science Monitor Basic Research


eISSN: 1643-3750

Get your full text copy in PDF

Effect of melatonin on two stage skin carcinogenesis in Swiss mice.

Arun C. Kumar, Unduri N. Das

Med Sci Monit 2000; 6(3): BR471-475

ID: 421324

Melatonin, a hormone secreted by the pineal gland, is known to have anti-mutagenicand oncostatic actions. This beneficial action of melatonin has been explained in terms of its abilityto scavenge free radicals and augment the activities of anti-oxidant enzymes. In the present study, weevaluated the effect of melatonin on benzo(a)pyrene-induced two stage skin carcinogenesis in mice andobserved that it can not only decrease the number of animals bearing papillomas but also the number ofpapillomas per animal both in the initiation and promotion stages of skin carcinogenesis. It was alsofound that melatonin treated animals have low levels of lipid peroxides and that it can also preventthe binding of BP or its metabolites to DNA. In view of these evidence, it can be suggested that melatoninmay function as an endogenous anti-mutagenic and oncostatic agent.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree