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MR proton spectroscopy in patients with CNS involvement in Bourneville's disease.

Eugeniusz Tarasów, Bożena Kubas, Jerzy Walecki

Med Sci Monit 2001; 7(4): MT762-765

ID: 421071

BACKGROUND: Despite much previous research, the origin of intracraniallesions in tuberous sclerosis is still unknown. We present MR and proton magnetic resonance (1H-MRS)studies of two patients with tuberous sclerosis.
MATERIAL AND METHODS: The study material consisted ofMR and 1H-MRS examinations from 2 patients (4-5 years old) with tuberous sclerosis. MR images (FSE, FAST,FLAIR) were obtained with a 1.5 T unit. Localized 1H-MRS studies (PRESS 35, TE 35 ms, TR 1500 ms, NEX192) on cortical (n=3) and subependymal (n=1) lesions were also performed. RESULTS: Decreased N-acatyloaspartate/creatine(NAA/Cr) and increased myoinositol/creatine (mI/Cr) ratios were observed in the spectra obtained fromthe subcortical and subependymal tubers.
CONCLUSIONS: Our observations confirm the hypothesis that disturbancesof migration, adhesion and differentiation of germ neuronal cells may underlay the pathogenesis of tuberoussclerosis.

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