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Medical Science Monitor Basic Research


eISSN: 1643-3750

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Effect of oral supplementation of free amino acids in type 2 diabetic patients: a pilot clinical trial.

Sivaramakrishna Ramakrishnan, Tharigopala Arokiasamy, Baluswamy Sukumar, Soundarajan Lakshmi, Konerirajapuram Natarajan Sulochana, Ranganathan Punitham

Med Sci Monit 2002; 8(3): CR131-137

ID: 420914

BACKGROUND: Oral amino acid intake reduces plasma glucose in Streptozotocin-induceddiabetic rats. This study examined the effect of oral amino acid supplementation in patients with type2 diabetes mellitus (DM). MATERIAL/METHODS: A double blind pilot clinical trial was conducted for a periodof 2 months on 77 subjects with type 2 DM. Subjects of both sexes, ages 30-60, were included in the trial.All were receiving oral antidiabetic tablets. They were divided into groups on the basis of oral supplementation:(A) lysine, (B) essential amino acids, (C) amino acids and vitamins (fat and water-soluble), and (D)calcium phosphate (control). The subjects were periodically examined for fasting and post-prandial plasmaglucose, fasting and post-prandial immunoreactive insulin, plasma amino acids, glycosylated haemoglobin(HbA1c), proteins and albumin in serum, urea and creatinine in plasma and sugar, and proteins and ketonesin urine. RESULTS: The results revealed a significant decrease in PP plasma glucose (P<0.05) in group B when compared to groups C and D after 45 days. Plasma Arginine was increased in group C from 3.84 to 9.24 mg/dl. There were no statistically significant changes seen in other parameters between groups and visits.
Conclusions:     Oral supplementation with amino acids for patients with type 2 DM appears to decrease PP plasma glucose without any change in plasma insulin levels, perhaps due to improved insulin sensitivity. However, the long term effects of amino acids need further study.

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