H-Index
79
Scimago Lab
powered by Scopus
JCR
Clarivate
Analytics
15%
Acceptance
Rate
call: +1.631.470.9640
Mon-Fri 10 am - 2 pm EST

Logo

Medical Science Monitor Basic Research
AmJCaseRep

Annals
ISI-Home

eISSN: 1643-3750

Get your full text copy in PDF

Exhaled breath condensate as a method of sampling airway nitric oxide and othermarkers of inflammation.

Jia Liu, Paul Thomas

Med Sci Monit 2005; 11(8): MT53-62

ID: 202430


Most of the methods of investigating lung diseases have been invasive untilthe discovery that exhaled nitric oxide can be used as a surrogate marker of airway inflammation, particularlyin asthma. Exhaled nitric oxide (NO) is now established as a marker of airway inflammation. It has beenshown to correlate well with eosinophilic asthmatic airway inflammation, and to be able to predict declinein asthma control and airway function. Altered levels of NO are also associated with other inflammatorylung diseases. In addition, polymorphisms of the genes encoding the three nitric oxide synthases areassociated with phenotypic differences associated with lung diseases. Exhaled NO is, however, non-specific.It is therefore of importance that collecting exhaled breath condensate (EBC) has emerged as a potentialtool in the study of pulmonary diseases. The exhaled breath is collected in a cooling system which allowswater vapour to condense. The EBC contains a number of mediators relating to the NO pathway, includingnitrite as a metabolite of nitric oxide, nitrotyrosine, nitrosothiols plus small molecular mediatorsassociated with oxidative stress, including hydrogen ions, and hydrogen peroxide. In addition, reportsare emerging of the detection of larger molecules which not only include leukotrienes, prostaglandins,albumin and other proteins, such as cytokines, but also macromolecules, for example, DNA. EBC is becominga technique which will allow repeated non-invasive sampling from the respiratory tract thus assistingpulmonary research and possibly the monitoring of lung diseases.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree