H-Index
79
Scimago Lab
powered by Scopus
JCR
Clarivate
Analytics
15%
Acceptance
Rate
call: +1.631.470.9640
Mon-Fri 10 am - 2 pm EST

Logo

Medical Science Monitor Basic Research
AmJCaseRep

Annals
ISI-Home

eISSN: 1643-3750

Get your full text copy in PDF

Doxorubicin-induced cataract formation in rats and the inhibitory effects of hazelnut, a natural antioxidant: A histopathological study

Atilla Bayer, Cem Evereklioglu, Erkan Demirkaya, Salih Altun, Yildirim Karslioglu, Gungor Sobaci

Med Sci Monit 2005; 11(8): BR300-304

ID: 201126


Background: To investigate whether hazelnut prevents doxorubicin-inducedexperimental cataract in rats. Material/Methods: Seventy-five 4-week-old male Wistar albino rats wererandomized into 5 equal groups. Beginning from 6 weeks of age, the groups were treated with intraperitonealinjections of saline solution or doxorubicin (DR) for 4 weeks. Group 1 received saline solution (0.5ml/200 g) weekly, groups 2 and 4 a cumulative dose of 6 mg/kg (1.5 mg/kg/week) of DR, and groups 3 and5 received a cumulative dose of 12 mg/kg (3 mg/kg/week) DR. All the rats were fed ad libitum with a 24%protein rodent chow. Groups 4 and 5 were additionally fed 5 g/day hazelnut. At the end of the tenth weekthe rats were sacrificed and cataract development was investigated histopathologically. The groups werestatistically compared. Results: All control lenses (group 1) were macroscopically clear. Cataractouschanges were noted in 7 eyes (47%) in group 2 and in 10 (67%) in group 3 (p=0.01). Groups 3 and 5 hadcataractous changes in 4 (27%) and 5 (33%) eyes, respectively (p=0.001). The cataract development ratiowas different between groups 2 and 4 (p=0.013), while there was no such difference between groups 3 and5 (p=0.053). Histopathological findings suggesting cataractogenesis were eosinophilic degeneration, corticallens-fiber cell swelling, and the retention of nuclei in central fibers. Conclusions: Hazelnut preventeddoxorubicin-induced cataract in low doses. Since it has no known harmful effect on healthy cells, itmay be beneficial in humans.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree