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eISSN: 1643-3750

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Antimicrobial susceptibility of aerobic microorganisms isolated from intraabdominal infections in pediatric patients in Poland

Katarzyna Dzierżanowska-Fangrat, Katarzyna Semczuk, Urszula Łopaciuk, Julianna Kurlenda, Eugeniusz Małafiej, Elżbieta Puacz, Ewa Stalmaska-Dworak, Danuta Dzierżanowska

Med Sci Monit 2005; 11(5): CR241-245

ID: 16145


Background: Growing resistance to antibiotics among both community-acquired and hospital pathogens is making the treatment of most infections increasingly difficult. Therefore, the aim of our multi-center study was to determine the antimicrobial susceptibility of the most frequent aerobic microorganisms isolated from children with intraabdominal infections. Material/Methods:Bacterial pathogens were isolated from 256 consecutive patients treated in five large specialized hospitals in Poland from January 2001 to February 2002. Minimal inhibitory concentrations (MICs) of piperacillin, piperacillin-tazobactam, cefotaxime, ceftazidime and cefepime were determined by Etests. The production of extended spectrum β-lactamases (ESBL) was detected by a double-disk test.Results: Piperacillin-tazobactam was the most active agent against Enterobacteriaceae and Pseudomonas aeruginosa, inhibiting 92% and 78% of isolates respectively. Susceptibility of Enterobacteriaceae to cefotaxime, ceftazidime and cefepime was 73%, 73% and 87% respectively, and susceptibility of P. aeruginosa to both ceftazidime and cefepime was 76%. Extended-spectrum &#x03B2-lactamases were detected in 56% Klebsiella sp. and 11.5% E. coli, but the vast majority of these isolates remained susceptible to piperacillin-tazobactam (MIC[sub]90[/sub]=12 mg/L and MIC[sub]90[/sub]=1 mg/L, respectively).Conclusions: Piperacillin/tazobactam remains a valuable therapeutic option in Polish pediatric patients with intraabdominal infections, due to its good activity against ES&#x03B2L-producing organisms and P. aeruginosa.

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