H-Index
79
Scimago Lab
powered by Scopus
JCR
Clarivate
Analytics
12%
Acceptance
Rate
call: +1.631.470.9640
Mon-Fri 10 am - 2 pm EST

Logo

Medical Science Monitor Basic Research
AmJCaseRep

Annals
ISI-Home

eISSN: 1643-3750

Get your full text copy in PDF

The influence of epithelium on the responsiveness of guinea-pig trachea to ß-adrenergic agonist and antagonist

Mohammad Hossein Boskabady, Simin Teymoory

Med Sci Monit 2003; 9(9): BR336-342

ID: 13139


Background:There is controversy regarding bronchial responsiveness to b2-agonist drugs in asthma. Epithelial shedding in the airways is a pathological feature of asthma. Therefore, the present study focused on the effect of epithelial denudation of guinea pig tracheal chains in response to isoprenaline and b-adrenergic receptor blockade.Material/Methods:In control (group 1, n=10), epithelium-denuded (group 2, n=10), and epithelium-denuded + epithelial cell (group 3 n=6) we measured the responses of tracheal chains to cumulative concentrations of isoprenaline (I) in the absence and presence of 10 nM propranolol, and the value of EC50I was calculated. The propranolol blockade (CR-1) was calculated as the ratio of post propranolol EC50I to initial EC50I.Results:The tracheal responses to isoprenaline (EC50I) in groups 2 and 3 was significantly higher than in the controls (p

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree