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A phase I study of a six-week cycle of immunotherapy with Murabutide in HIV-1 patients na¨Ive to antiretrovirals

Xavier De La Tribonniere, Yves Mouton, Vincent Vidal, Edith Darcissac, Daouda Sissoko, Clothilde Fontier, Youcef Douadi, Joƫlle Dewulf, Corinne Amiel, George Michael Bahr

Med Sci Monit 2003; 9(6): PI43-50

ID: 12743

Background:Limitations in the use of antiretroviral therapy suggest the need for additional approaches to enhance immune restoration and the control of HIV-1 replication. Therefore, we evaluated the clinical tolerance and biological effects of immunotherapy with the synthetic immunomodulator Murabutide in 9 treatment-na¨lve HIV-1 patients presenting with CD4+ lymphocyte counts >500 cells/mm3 and plasma viral loads

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