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Long-term efficacy of steady-dose metformin in type 2 diabetes mellitus: a retrospective study

Józef Drzewoski, Leszek Czupryniak

Med Sci Monit 2003; 9(6): CR240-243

ID: 12742

Background:Few data are available on the long-term efficacy of metformin, one of the main drugs in the treatment of type 2 diabetes mellitus.Material/Methods:This was a retrospective study of 195 type 2 diabetic patients (109 female, 86 male; mean age 50.4±10.1 years, diabetes duration 5.4±1.4 years, mean BMI 28.6±6.5 kg/m2 at baseline). The inclusion criterion was at least one-year treatment with metformin alone or metformin and one other antidiabetic drug in unchanged doses. The analysis included duration of metformin treatment, mode of therapy, changes in metabolic parameters (fasting blood glucose, HbA1c), body weight, and insulin dosage.Results:Mean duration of metformin use was 970±578 (range 373–2916) days, mostly 500 mg tid. 42 patients (22%) were treated with metformin only, 82 (42%) with metformin and sulfonylurea, 61 (31 %) with metformin and insulin and 10 (5%) with metformin and acarbose. In the whole group mean fasting blood glucose decreased during the treatment significantly, from 212±57 to 167±54 mgldl (p

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