Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

20 May 2004

Intrauterine foetal infection by Cytomegaly Virus – dependencebetween the CMV presence intensification in amniotic fluidand neonatal well-being

Grzegorz Machnik, Urszula Mazurek, Bartosz Czuba, Helena Sławska, Kazimierz Kamiński, Tadeusz Wilczok

Med Sci Monit 2004; 10(2): 53-57 :: ID: 11853

Abstract

Background: Difficulties during interpretation of serological tests carried out to detect Cytomegaly in pregnant patients and difficulties in evaluating intrauterine transmission of the infection to a foetus is the reason for use of the Polimerase Chain Reaction (PCR) for Cytomegaly Virus (CMV) detection. To evaluate the dependence between CMV presence intensification and a neonate’s well being, the quantitative PCR (QPCR) method was applied.Material and Methods: The samples of amniotic fluid from 128 patients were examined for the presence of CMV. Pregnancy duration and premature parturition frequency were analysed. Neonates’ condition, birth weight and hypotrophy occurrence frequency were defined. The frequency of occurrence of hepatomegaly, thrombocytopenia, pneumonia, hiperbilirubinemia, brain ventricle broadening and intracranial calcification were evaluated, as well as their dependence to the amount of the CMV genetic material found in amniotic fluid.Results: The presence of the CMV genome in amniotic fluid was confirmed in 35.5% of the patients. Between 2 900 and 1 000 000 virus genome copies in 1 ml of amniotic fluid were found. Average duration of gestation in the study group was 34.3 weeks. A high percentage of premature births (66%) amongst patients with CMV genetic material in amniotic fluid was revealed. There was no dependence found between the number of CMV genome copies in amniotic fluid and pregnancy duration or premature parturition or congenital cytomegaly symptoms occurrence.Conclusions: The high number of diagnosed viral transmissions from mothers to a foetuses in the pathological pregnancies and the frequency of premature parturitions in CMV infected group indicate the need for prenatal diagnosis of CMV.

Keywords: cytomegalovirus infection, newborn, Polymerase Chain Reaction

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750