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Urinary levels of interleukin-6 and interleukin-8 in children with urinary tract infections to age 2.

Grażyna Krzemień, Maria Roszkowska-Blaim, Izabella Kostro, Agnieszka Szmigielska, Monika Karpińska, Maria Sieniawska, Irena Bartłomiejczyk, Leszek Pączek, Krzysztof Toth

Med Sci Monit 2004; 10(11): CR593-597

ID: 11800

BACKGROUND: The aim of this study was to assess relations between the clinical course of UTI, IL-6 and IL-8 levels, and the presence of inflammatory changes detected by renal scintigraphy using 99mTc-DMSA (DMSA). MATERIAL/METHODS: We studied 33 children aged 1-24 months (mean 7.1+/-5.8 months) with first-time UTI. The subjects were divided in two groups: with fever (group I, n=10) and without fever (group II, n=23). Inflammatory markers (ESR, CRP, leukocyte count), urinary IL-6 and IL-8 level, and DMSA scan were evaluated in all children. RESULTS: Urinary IL-6 and IL-8 levels [IL-6, IL-8/creatinine (pg/mg)] were significantly higher in group I than in group II (Il-6 level: 39.4+/-41.1 vs. 6.3+/-13.7, p

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