Scimago Lab
powered by Scopus
call: +1.631.470.9640
Mon-Fri 10 am - 2 pm EST


Medical Science Monitor Basic Research


eISSN: 1643-3750

Get your full text copy in PDF

Suppression of gastric acid production may improve the course of angina pectoris and the results of treadmill stress test in patients with coronary artery disease

Maciej Świątkowski, Jacek Budzyński, Maria Kłopocka, Grzegorz Pulkowski, Karol Suppan, Jacek Fabisiak, Włodzimierz Morawski, Marcin Majer

Med Sci Monit 2004; 10(9): CR524-529

ID: 11758

Background:Juvenile nasopharyngeal angiofibroma (JNA)is a benign neoplasm, which represents less than 0,05%of all head and neck tumours. It affects almost solely adolescent males. Surgery is the main treatment modality. he purpose of this study was to present, based on 24 cases ,typical JNA features on CT and MRI.Material/Methods: We studied 34 patients with stable angina pectoris. In all subjects a medical history, a physical examination, and a stress test were performed at the beginning of the study and after two weeks of add-on rabeprazole therapy (20 mg b.i.d.).Results: Rabeprazole therapy significantly improved the outcome of the stress test in 27 patients (79%), prolonging mean stress exercise time (449±147 vs. 489±156s, p=0.027) and exercise time, leading to a maximum ST interval depression (360±167 vs. 467±148s, p=0.001), and also decreasing ST interval depression delta (1.9±1.1 vs. 1.5±0.9; p=0.013).Conclusions: In 79% of our study subjects, rabeprazole improved stress test results in CAD patients, which implies that at least some of their symptoms were related to GERD. A proton pump inhibitor exerted a favorable effect on the frequency of angina-like chest pain and the results of the treadmill stress test.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree