01 February 2018 : Case report
Non Uremic Calciphylaxis Post Liver Transplantation: A Case Report and Literature Review of an Unusual Presentation of a Rare Disease
Challenging differential diagnosis, Rare disease
Swati Prabhakar1ABEF, Ahmad M. Tuffaha1ABCDEFG*DOI: 10.12659/AJCR.906981
Am J Case Rep 2018; 19:118-122
Abstract
BACKGROUND: Calciphylaxis results from abnormal calcification of small to medium sized vessels, resulting in painful ischemic necrosis of the surrounding tissues. It is most commonly seen in patients with end stage renal disease on dialysis, but has also been reported in patients with preserved renal function.
CASE REPORT: We report a case of non uremic calciphylaxis in a 65-year-old female who presented with painful skin lesions and ulcerations involving both thighs one month after receiving a liver transplantation. She was treated with sodium thiosulfate along with wound care and hyperbaric oxygen with complete resolution of the lesions, but with residual scarring.
CONCLUSIONS: Non uremic calciphylaxis is a rare phenomenon that is poorly understood. It should be in the differential of unexplained skin lesions even in the absence of renal insufficiency. Sodium thiosulfate plays a role in treatment, but wound care remains the main focus of treatment.
Keywords: calciphylaxis, Sodium Thiosulfate, Hyperbaric Oxygenation
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