11 May 2022: Clinical Research
Consistency Analysis of 3 Detection Systems for Measuring Serum C-Reactive Protein
Xueyan Chen 1AEF* , Chuanyihong Huang 1AEF* , Weichuan Zhong 1BCD , Suwen Qi 2BCD , Ting Huang 3BCD , Zihua Yang 4AE*DOI: 10.12659/MSM.935171
Med Sci Monit 2022; 28:e935171
Table 1 Consistency of the Mindray BC-5390 and BC-6800 analyzers in routine blood indicators.
| Variables | BC-5390 | BC-6800 | P | R | Passing-Bablok | Bland-Altman | |
|---|---|---|---|---|---|---|---|
| Intercept | Slope | ||||||
| WBC, 10/L, M (Q, Q) | 11.02 (8.11, 14.32) | 10.84 (8.00,13.88) | 0.993 | 0.066 (−0.026, 0.160) | 0.972 (0.963, 0.981) | −0.217 (−1.478, 1.045) | |
| Neutrophils, %, mean±SD | 77.38±10.52 | 77.76±10.31 | 0.99 | 1.782 (1.094, 2.449) | 0.980 (0.971, 0.988) | 0.334 (−2.497, 3.165) | |
| Lymphocytes, %, M (Q, Q) | 12.90 (8.50, 18.40) | 12.40 (8.20, 18.00) | 0.989 | −0.034 (−0.167, 0.099) | 0.976 (0.966, 0.985) | −0.527 (−3.006, 1.953) | |
| Monocytes, %, M (Q, Q) | 6.30 (4.90, 7.80) | 6.70 (5.20, 8.20) | 0.917 | 0.092 (−0.028, 0.300) | 1.030 (1.000, 1.049) | 0.277 (−1.713, 2.267) | |
| Eosinophils, %, M (Q, Q) | 0.70 (0.20, 1.50) | 0.50 (0.10, 1.30) | 0.986 | −0.100 (−0.100, −0.100) | 1.000 (1.000, 1.000) | −0.106 (−0.852, 0.640) | |
| Basophils, %, M (Q, Q) | 0.20 (0.10, 0.30) | 0.20 (0.10, 0.30) | 0.42 | 0.000 (0.000, 0.000) | 1.000 (1.000, 1.000) | 0.022 (−0.379, 0.423) | |
| Neutrophils, 10/L, M (Q, Q) | 8.65 (5.90, 11.84) | 8.49 (5.94, 11.42) | 0.994 | 0.123 (0.069, 0.190) | 0.966 (0.958, 0.975) | −0.155 (−1.263, 0.953) | |
| Lymphocytes, 10/L, M (Q, Q) | 1.38 (0.95, 1.85) | 1.32 (0.88, 1.76) | 0.982 | −0.036 (−0.056, −0.017) | 0.979 (0.964, 0.996) | −0.069 (−0.356, 0.218) | |
| Monocytes, 10/L, M (Q, Q) | 0.68 (0.49, 0.92) | 0.70 (0.50, 0.96) | 0.962 | 0.003 (−0.008, 0.020) | 1.025 (1.000, 1.043) | 0.018 (−0.172, 0.208) | |
| Eosinophils, 10/L, M (Q, Q) | 0.07 (0.03, 0.15) | 0.05 (0.01, 0.12) | 0.986 | −0.010 (−0.010, −0.010) | 1.000 (1.000, 1.000) | −0.012 (−0.082, 0.059) | |
| Basophils, 10/L, M (Q, Q) | 0.02 (0.01, 0.03) | 0.02 (0.01, 0.03) | 0.009 | 0.318 | 0.000 (0.000, 0.000) | 1.000 (1.000, 1.000) | 0.001 (−0.037, 0.039) |
| RBC, 10/L, mean±SD | 4.40±0.93 | 4.20±0.88 | 0.99 | −0.048 (−0.085, −0.005) | 0.960 (0.950, 0.969) | −0.223 (−0.491, 0.046) | |
| Hemoglobin, g/L, mean±SD | 129.32±27.29 | 126.38±27.60 | 0.996 | −4.918 (−5.774, −3.000) | 1.013 (1.000, 1.020) | −3.254 (−8.109, 1.601) | |
| Hematocrit, %, mean±SD | 37.99±7.64 | 37.28±7.61 | 0.986 | −1.100 (−1.502, −0.757) | 1.000 (0.990, 1.011) | −0.928 (−3.445, 1.589) | |
| MCV, fL, mean±SD | 86.89±7.66 | 89.33±7.82 | 0.000 | 0.983 | 2.400 (0.945, 3.321) | 1.000 (0.990, 1.018) | 2.333 (−0.337, 5.004) |
| MCH, pg, mean±SD | 29.55±3.05 | 30.22±3.10 | 0.966 | 0.800 (0.202, 0.947) | 1.000 (0.992, 1.020) | 0.741 (−0.783, 2.265) | |
| MCHC, g/L, mean±SD | 339.90±15.15 | 337.89±10.81 | 0.044 | 0.733 | 128.276 (113.000, 141.085) | 0.621 (0.583, 0.667) | −0.701 (−20.550, 19.148) |
| RDW-CV, %, mean±SD | 13.30±1.86 | 13.41±1.80 | 0.958 | 1.033 (0.622, 1.450) | 0.933 (0.900, 0.967) | 0.107 (−0.825, 1.039) | |
| RDW-SD, fL, mean±SD | 42.48±6.18 | 42.56±5.42 | 0.864 | 0.955 | 7.183 (6.359, 8.102) | 0.833 (0.811, 0.854) | 0.010 (−3.384, 3.405) |
| Platelets, 10/L, M (Q, Q) | 230.00 (180.00, 284.00) | 225.00 (178.00, 276.00) | 0.979 | 2.426 (−0.693, 5.297) | 0.966 (0.952, 0.980) | −4.684 (−42.211, 32.842) | |
| Plateletcrit, %, M (Q, Q) | 0.22 (0.18, 0.27) | 0.21 (0.17, 0.25) | 0.958 | 0.002 (−0.002, 0.006) | 0.948 (0.929, 0.970) | −0.009 (−0.054, 0.036) | |
| MPV, fL, mean±SD | 9.69±1.18 | 9.51±1.29 | 0.918 | −1.244 (−1.580, −0.857) | 1.111 (1.071, 1.148) | −0.187 (−1.054, 0.681) | |
| PDW, %, mean±SD | 15.96±0.79 | 15.98±0.81 | 0.009 | 0.815 | 0.000 (0.000, 0.000) | 1.000 (1.000, 1.000) | 0.022 (−0.465, 0.510) |
| R – correlation coefficient; WBC – white blood cells; RBC – red blood cells; MCV – mean corpuscular volume; MCH – mean corpuscular hemoglobin; MCHC – mean corpuscular hemoglobin concentration; RDW-CV – RBC distribution width-coefficient of variation); RDW-SD – RBC distribution width-standard deviation; MPV – mean platelet volume; PDW – platelet distribution width. | |||||||