07 January 2022: Meta-Analysis
Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Disease: A Meta-Analysis
Wenjie Sun AE , Junqiang Yan AFG* , Jiannan Wu BC , Hongxia Ma BDDOI: 10.12659/MSM.935074
Med Sci Monit 2022; 28:e935074
Table 3 Methods of measuring primary outcomes and summary of finding (SoF). GRADEprofiler was used to create the table.
| Outcomes | Study ID/number of participants (PD/control) | Summary of findings | ||||||
|---|---|---|---|---|---|---|---|---|
| Videnovic 2017 | Rutten 2016–2019 | Rutten 2019 | Raymackers 2019 | Willis 2018 | ||||
| 16/15 | 35/37 | 45/47 | 8/8 | 10/10 | Difference from pre to post (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | |
| Motor function | UPDRS III | UPDRS III | UPDRS III | UPDRS III | 4.68 lower (8.25 to 1.12 lower) | 209 (4 studies) | ⊕⊕⊕⊕ high | |
| Depression | BDI | HDRS | BDI | HADS (depression) | BDI | 0.27 standard deviations lower (0.52 to 0.01 lower) | 234 (5 studies) | ⊕⊕⊕⊕ high |
| Daytime sleepiness | ESS | SCOPA (daytime sleepiness) | ESS | ESS | ESS | 0.14 standard deviations lower (0.39 lower to 0.11 higher) | 241 (5 studies) | ⊕⊕⊕⊕ high |
| Sleep | PDSS | PDSS | 3.45 standard deviations higher (0.12 to 6.78 higher) | 122 (2 studies) | ⊕⊕⊕⊕ high | |||
| Adverse events | RR 1.73 (1.19 to 2.52) | 231 (5 studies) | ⊕⊕⊕⊕ high | |||||
| SCOPA (daytime sleepiness) – Scales for Outcomes in Parkinson’s Disease (daytime sleepiness); PDSS – Parkinson’s Disease Sleep Scale; FSS – Fatigue Severity Scale; FIS – Fatigue Impact Scale; BBS – Brief Bronowski Scale; BAI – Beck Anxiety Inventory; PDQ-39; WHO-QOL – World Health Organization-Quality of Life assessment. * The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI – confidence interval; RR – risk ratio; GRADE Working Group grades of evidence. Further research is very unlikely to change our confidence in the estimate of effect. Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. We are very uncertain about the estimate. | ||||||||