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02 January 2022: Clinical Research

Retrospective Study of 573 Patients with Heart Failure Evaluated for Coronary Artery Disease at Toulouse University Center, France

Antoine Deney 1ABCDEF* , Vanessa Nader 12ABCDEF* , Anthony Matta 13ABCDE , Romain Itier 1CDE , Pauline Fournier 1ABCD , Olivier Lairez 1ADF , Nathalie Pizzinat 4ACD , Didier Carrié 1ACD , Frédéric Boal 4ACD , Michel Galinier 1ACD , Oksana Kunduzova 4ACD , Rania Azar 2ACD , Jerome Roncalli 14ABCDEFG*

DOI: 10.12659/MSM.934804

Med Sci Monit 2022; 28:e934804

Table 4 Characteristics of heart failure with reduced ejection fraction (HFrEF) group stratified by the presence of coronary artery disease.

HFrEF populationN=484No CADN=214Significant CADN=270P-value
Age67.50±12.5163.86±13.7970.38±10.57
Male sex375 (77.48%)148 (69.16%)227 (84.41%)
BMI27.89±19.5030.27±28.7226.08±4.690.036
Atrial fibrillation149 (30.78%)65 (30.37%)84 (31.11%)0.861
Chronic kidney disease221 (45.66%)66 (30.84%)155 (57.41%)
Dyslipidemia125 (25.82%)44 (20.56%)81 (30.00%)0.080
Diabetes142 (29.34%)48 (22.43%)94 (34.81%)0.020
Hypertension248 (51.24%)86 (40.18%)162 (60.00%)0.001
Smoking133 (27.48%)56 (26.17%)77 (28.52%)0.906
Family history78 (16.12%))38 (17.76%)40 (14.81%)0.164
Valvopathy195 (40.29%)81 (37.85%)114 (42.22%)0.317
RVD104 (21.49%)49 (22.89%)55 (20.37%)0.244
TAPSE16.78±4.5016.15±4.3617.26±4.550.053
PAPSE41.46±13.6341.53±12.7541.41±14.300.963
Pacemaker35 (7.23%)15 (7.10%)20 (7.41%)0.860
Defibrillator37 (7.64%)12 (5.61%)25 (9.26%)0.133
NYHA
 123 (4.75%)10 (4.67%)13 (4.81%)1
 2126 (26.03%)56 (26.17%)70 (25.93%)
 3129 (26.65%)56 (26.17%)73 (27.04%)
 443 (8.88%)19 (8.89%)24 (8.88%)
Systolic blood pressure127.37±22.55126.62±22.02127.95±22.990.566
Diastolic blood pressure75.67±14.9077.02±15.5374.62±14.350.118
Heart rate82.76±21.1686.13±20.9980.13±20.970.005
Troponin149.21±58.7887.71±269.36186.97±705.820.262
NT-ProBNP5770.14±8697.025341.15±8308.366135.28±9017.840.365
β-blockers283 (58.47%)113 (52.80%)170 (62.96%)0.024
Diuretics278 (57.44%)116 (54.20%)162 (60.00%)0.184
Mineralocorticoids84 (17.35%)36 (16.82%)48 (17.77%)0.783
ACE/ARA238 (49.17%)90 (42.05%)148 (54.81%)0.006
ARNI42 (8.67%)18 (8.41%)24 (8.89%)0.853
Ivabradine7 (1.45%)2 (0.93%)5 (1.85%)0.471
SAPT136 (28.10%)33 (15.42%)103 (38.15%)
DAPT39 (8.06%)3 (1.40%)36 (13.33%)
DOAC+AVK138 (28.51%)59 (27.57%)79 (29.26%)0.683
AAP+OAC29 (5.99%)4 (1.87%)25 (9.26%)0.001
β-blockers422 (87.19%)187 (87.38%)235 (87.03%)0.748
Diuretics377 (77.89%)169 (78.97%)208 (77.04%)0.837
Mineralocorticoids212 (43.80%)105 (49.06%)107 (39.63%)0.047
ACE/ARA267 (55.16%)122 (57.01%)145 (53.70%)0.545
ARNI133 (27.48%)68 (31.77%)65 (24.07%)0.064
Ivabradine17 (3.51%)7 (3.27%)10 (3.70%)0.774
SAPT87 (17.97%)30 (14.02%)57 (21.11%)0.037
DAPT186 (38.43%)12 (5.61%)174 (64.44%)
DOAC+AVK191 (39.46%)90 (42.06%)101 (37.41%)0.299
AAP+OAC71 (14.67%)3 (1.40%)68 (25.18%)

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750