10 March 2022: Database Analysis
Prognostic Nutritional Index as a Predictor of 30-Day Mortality Among Patients Admitted to Intensive Care Unit with Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Single-Center Retrospective Cohort Study
JiangChen Peng E , Fang Nie A , YuJie Li C , QiaoYi Xu F , ShunPeng Xing D , Yuan Gao E*DOI: 10.12659/MSM.934687
Med Sci Monit 2022; 28:e934687
Table 1 Baseline and clinical characteristics of the study population.
| Characteristics | Low tertile (≤30.2, n=164) | Middle tertile (30.2–36.2, n=165) | High tertile (>36.2, n=165) | P value |
|---|---|---|---|---|
| Age, years (mean±SD) | 71.4±9.8 | 71.8±10.3 | 69.1±10.9 | 0.039 |
| Sex, n (%) | ||||
| Male | 84 (51.2%) | 79 (47.9%) | 85 (51.5%) | 0.776 |
| Female | 80 (48.8%) | 86 (52.1%) | 80 (48.5%) | 0.776 |
| Biochemistry, median (IQR) | ||||
| WBC count (10/μL) | 11.3 (8.5, 15.7) | 11.2 (7.9, 15.9) | 10.7 (7.8, 15.0) | 0.377 |
| Neutrophil count (10/μL) | 9.8 (7.0, 13.7) | 9.5 (6.1, 14.0) | 8.1 (5.7, 12.7) | |
| Lymphocyte count (10/μL) | 0.7 (0.3, 1.2) | 1.0 (0.5, 1.7) | 1.2 (0.6, 1.9) | |
| Platelet count (10/μL) | 229 (162, 307) | 245 (175, 311) | 238 (186, 300) | 0.508 |
| Hemoglobin (g/dL) | 10.4 (9.3, 11.5) | 10.9 (9.6, 12.4) | 11.3 (9.9, 12.7) | |
| Serum albumin (g/dL) | 2.4 (2.63, 2.8) | 3.2 (3.1, 3.3) | 3.8 (3.6, 4.0) | |
| Serum sodium (mmol/L) | 137 (134, 141) | 138 (134, 141) | 138.0 (135, 140) | 0.958 |
| Serum potassium (mmol/L) | 4.1 (3.5, 4.6) | 4.3 (3.7, 4.7) | 4.2 (3.8, 4.7) | 0.085 |
| Serum calcium (mmol/L) | 1.11 (1.06, 1.08) | 1.14 (1.06, 1.20) | 1.15 (1.09, 1.18) | 0.270 |
| pH | 7.33 (7.26, 7.41) | 7.33 (7.23, 7.39) | 7.34 (7.25, 7.39) | 0.434 |
| PO2 (mmHg) | 105 (72, 207) | 101.0 (74, 183) | 105.0 (74, 169) | 0.882 |
| PCO2 (mmHg) | 53 (43, 67) | 55.0 (46, 71) | 55.0 (45, 79) | 0.112 |
| Bicarbonate (mmol/L) | 28 (24, 32) | 28 (25,33) | 29 (25, 34) | 0.124 |
| ALT (IU/L) | 22 (15, 44)) | 26 (16, 41) | 21 (15, 35) | 0.208 |
| AST (IU/L) | 28 (17, 46) | 29 (19, 48) | 23 (17, 38) | 0.044 |
| Creatinine (mg/dL) | 1.0 (0.7, 1.4) | 1.0 (0.7, 1.3) | 1.0 (0.75, 1.4) | 0.790 |
| BUN (mmol/L) | 28 (20, 41) | 24 (17, 37) | 23 (18, 34) | 0.045 |
| Vital signs, median (IQR) | ||||
| Temperature (°C) | 36.7 (36.3, 37.1) | 36.7 (36.3, 37.1) | 36.7 (36.3, 37.0) | 0.533 |
| MAP (mmHg) | 74 (68, 84) | 79 (71, 85) | 78 (73, 86) | 0.011 |
| Heart rate (min) | 92 (81, 101) | 88 (77, 97) | 88 (80, 99) | 0.136 |
| Respiratory rate (min) | 20 (17, 23) | 21 (17, 23) | 20 (18, 23) | 0.873 |
| Inflammatory indicators, median (IQR) | ||||
| NLR | 14.7 (7.4, 29.3) | 8.9 (5.4, 14.3) | 6.6 (3.9, 14.2) | |
| PLR | 311.4 (175.6, 621.1) | 230.6 (119.5, 461.1) | 198.6 (122.3, 355.4) | |
| Comorbidities, n (%) | ||||
| Hypertension | 75 (45.7%) | 80 (48.5%) | 91 (55.2%) | 0.214 |
| DM | 42 (25.6%) | 38 (23.0%) | 57 (34.5%) | 0.051 |
| CHD | 37 (22.6%) | 46 (27.9%) | 51 (30.9%) | 0.226 |
| CKD | 28 (17.1%) | 27 (16.4%) | 28 (17.0%) | 0.983 |
| Malignancy | 41 (25.0%) | 47 (28.5%) | 43 (26.1%) | 0.764 |
| Scoring system, median (IQR) | ||||
| SAPSII | 40 (33, 49) | 40 (33, 48) | 37 (29, 45) | 0.033 |
| SOFA | 5 (3, 7) | 4 (2, 6) | 4 (2, 6) | 0.057 |
| Normally distributed data are presented as the mean±SD, non-normally distributed data are presented as median (IQR) and categorical variables are presented as n (%). WBC – white blood cell; BUN – blood urea nitrogen; ALT – alanine transaminase; AST – aspartate transaminase; MAP – mean atrial pressure; NLR – neutrophil-to-lymphocyte ratio; PLR – platelet-to-lymphocyte ratio; DM – diabetes mellitus; CAD – coronary heart disease; CKD – chronic kidney disease; SAPSII – simplified acute physiology score II; SOFA – sequential organ failure assessment. | ||||