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30 October 2021: Database Analysis

Construction and Verification of a Hypoxia-Stemness-Based Gene Signature for Risk Stratification in Esophageal Cancer

Kang Tang 1BCDE , Yong Cheng 2AF , Qian Li 3AF*

DOI: 10.12659/MSM.934359

Med Sci Monit 2021; 27:e934359

Table 3 Univariate and multivariate Cox regression analysis of clinicopathological characteristics associated with overall survival in the TCGA-ESCA cohort.

VariablesUnivariate analysisMultivariate analysis
HR (95% CI)P-valueHR (95% CI)P-value
Gender2.354 (0.728, 7.605)0.153
Stage2.671 (1.800, 3.964)* 1.582 (0.593, 4.220)0.359
T stage1.257 (0.866, 1.824)0.228
N stage1.819 (1.294, 2.556)* 1.580 (0.887, 2.815)0.120
M stage4.847 (2.211, 10.626)* 2.551 (0.413, 15.742)0.313
Risk score3.346 (2.054, 5.452)* 4.172 (2.429, 7.165)*
HR – hazard ratio; CI – confidence interval.
* Statistically significant.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750