Construction and Verification of a Hypoxia-Stemness-Based Gene Signature for Risk Stratification in Esophageal Cancer

30 October 2021: Database Analysis

Kang Tang ^1BCDE , Yong Cheng ^2AF , Qian Li ^3AF*

DOI: 10.12659/MSM.934359

Med Sci Monit 2021; 27:e934359

Table 2 Univariate analysis of expression of 14 hypoxia-stemness base prognostic genes with overall survival.

Gene symbol	Univariate z score	HR	95% CI	P value
GAS1	3.024	1.449	(1.139, 1.842)	0.002
FABP1	2.973	1.331	(1.102, 1.607)	0.003
EPCAM	2.457	1.364	(1.065, 1.748)	0.014
ARSE	2.456	1.326	(1.059, 1.661)	0.014
CLDN3	2.438	1.334	(1.058, 1.682)	0.015
AMTN	2.304	1.215	(1.029, 1.433)	0.021
CYP2W1	2.294	1.251	(1.033, 1.514)	0.022
IL17RB	2.259	1.274	(1.033, 1.572)	0.024
CLRN3	2.193	1.330	(1.031, 1.717)	0.028
CLDN7	2.079	1.287	(1.015, 1.633)	0.038
FOXA2	2.017	1.284	(1.007, 1.638)	0.044
HHLA2	2.000	1.238	(1.004, 1.527)	0.046
FBLN2	−1.980	0.691	(0.480, 0.996)	0.048
CTSF	1.980	1.264	(1.002, 1.594)	0.048
HR – hazard ratio risk; CI – confidence interval.