15 January 2022: Database Analysis
Prediction of Patient Survival with Psoas Muscle Density Following Transjugular Intrahepatic Portosystemic Shunts: A Retrospective Cohort Study
Biyu Zhang ABCDEF , Weimin Cai ABCDEF , Feng Gao BE , Xinran Lin BC , Ting Qian F , Kaier Gu B , Bingxin Song B , Tanzhou Chen A*DOI: 10.12659/MSM.934057
Med Sci Monit 2022; 28:e934057
Table 1 Characteristics of the study population, stratified by survival event.a
| Variables | All patients n=273 | Nonsurvivor n=31 | Survivor n=242 | P valueb |
|---|---|---|---|---|
| Basic information | ||||
| Age, y | 53.54±10.51 | 57.55±9.63 | 53.02±10.53 | 0.024 |
| BMI | 22.67 (20.51–25.01) | 22.76 (20.49–25.17) | 22.19 (20.69–23.82) | 0.590 |
| Sex | ||||
| Male | 194 | 22 | 172 | 0.990 |
| Female | 79 | 9 | 70 | |
| Diabetes | 69 | 12 | 57 | 0.068 |
| Hypertension | 27 | 3 | 24 | 0.932 |
| Smoking | 105 | 11 | 94 | 0.717 |
| Splenectomy | 22 | 1 | 21 | 0.294 |
| Etiology of cirrhosis | 0.115 | |||
| Alcoholic | 53 | 6 | 47 | |
| Viral (HBV or HCV) | 151 | 14 | 137 | |
| Both alcohol and viral | 35 | 3 | 32 | |
| Othersc | 34 | 8 | 26 | |
| Reasons for TIPS | 0.563 | |||
| EGVB | 246 | 26 | 220 | |
| RF | 13 | 3 | 10 | |
| Portal vein thrombosis | 7 | 1 | 6 | |
| Othersd | 7 | 1 | 6 | |
| TIPS targeted puncture | 0.007 | |||
| Left branch of the intrahepatic portal vein | 199 | 20 | 179 | |
| Right branch of the intrahepatic portal vein | 61 | 6 | 55 | |
| Otherse | 13 | 5 | 8 | |
| Laboratory parameters | ||||
| RBC, ×10 | 2.93 (2.47–3.44) | 2.91 (2.53–3.46) | 2.93 (2.47–3.44) | 0.788 |
| WBC, ×10 | 3.79 (2.51–36.33) | 3.60 (2.90–4.86) | 3.85 (2.45–6.54) | 0.695 |
| Lymphocyte, ×10 | 0.76 (0.51–1.19) | 0.72 (0.50–0.97) | 0.77 (0.52–1.25) | 0.461 |
| Neutrophil, ×10 | 2.42 (1.51–4.30) | 2.46 (1.54–3.60) | 2.42 (1.49–4.33) | 0.659 |
| Platelet, ×10 | 64.0 (45.5–92.5) | 56.0 (42.0–85.0) | 64.5 (46.5–93.3) | 0.415 |
| Hemoglobin, g/L | 83.0 (69.0–97.0) | 86.0 (75.0–101.0) | 82.5 (69.0–96.0) | 0.306 |
| Albumin, g/L | 30.18±5.39 | 28.34±4.10 | 30.41±5.49 | 0.015 |
| Total bilirubin, μmol/L | 20.0 (13.5–29.5) | 20.0 (13.5–29.5) | 19.0 (13.0–28.0) | 0.003 |
| ALT, U/L | 24.0 (17.0–36.0) | 39.0 (20.0–52.0) | 23.0 (17.0–34.0) | 0.007 |
| AST, U/L | 35.0 (26.5–52.0) | 50.0 (33.0–86.0) | 35.0 (25.0–48.0) | 0.001 |
| Serum creatinine, μmol/L | 64.0 (52.0–75.0) | 63.0 (50.0–79.0) | 64.0 (53.0–75.0) | 0.698 |
| Serum sodium, mmol/L | 138.0 (135.0–141.0) | 138.0 (134.0–140.0) | 138.0 (136.0–141.0) | 0.383 |
| Prothrombin time, s | 16.9 (15.6–18.5) | 17.2 (16.0–19.4) | 16.9 (15.6–18.4) | 0.146 |
| PMD, HU | 51.7 (46.4–55.1) | 47.5 (43.4–50.4) | 52.2 (47.1–55.4) | |
| INR | 1.40 (1.26–1.58) | 1.39 (1.24–1.60) | 1.41 (1.27–1.58) | 0.402 |
| Clinical scores | ||||
| Child-Pugh score | 7 (6–9) | 8 (7–9) | 7 (6–9) | 0.090 |
| MELD score | 11.45 (9.72–13.63) | 12.02 (10.67–14.39) | 11.29 (9.57–13.58) | 0.081 |
| MELD-Na score | 10.92 (7.47–14.50) | 12.92 (9.13–15.33) | 12.92 (9.13–15.33) | 0.147 |
| ALT – alanine aminotransferase; AST – aspartate aminotransferase; BMI – body mass index; EGVB – esophageal gastric-fundus variceal bleeding; HBV – hepatitis B virus; HCV – hepatitis C virus; HU – Hounsfield units; INR – international standardization ratio; MELD – model for end-stage liver disease; MELD-Na – composite index of model for end-stage liver disease and serum sodium; PMD – psoas muscle density; RBC – red blood cell count; RF – refractory ascites; TIPS – transjugular intrahepatic portosystemic shunt; WBC – white blood cell count. a Data were tested for normality. Descriptive statistics are expressed as numbers or mean values (±SD), as appropriate. Continuous variables are expressed as means±SD or medians with interquartile ranges. b The test or the Mann-Whitney U test was used to compare 2 groups, and χ test or Fisher exact test was used to compare categorical variables. c Others included primary biliary cirrhosis, autoimmune diseases, Budd-Chiari syndrome, and cryptogenic cirrhosis. d Others included preventive therapy, portal system thrombosis, and alleviation of abdominal discomfort. e Others included portal vein trunk, right branches of the portal vein, and confluence of the left branches of the portal vein. | ||||