Pretreatment with Methylene Blue Protects Against Acute Seizure and Oxidative Stress in a Kainic Acid-Induced Status Epilepticus Model

10 October 2021: Animal Study

Yong-feng Wang ^1E* , Yan Luo ^2C* , Gao-lei Hou ^1B , Rui-jing He ^3C , Hao-yun Zhang ^3F , Yan-Li Yi ^3D , Ying Zhang ^3B , Zhi-qiang Cui ^3AG*

DOI: 10.12659/MSM.933469

Med Sci Monit 2021; 27:e933469

Table 1 Effect of MB on KA-induced acute seizure onset in mice. Data are mean ± SEM for latency to different seizure phase.

Group	Latent time (min)			Percentage of incidence of SE (%)	Survival percentage (%)
Group	Phase 1–3	Phase 4–5	Phase SE	Percentage of incidence of SE (%)	Survival percentage (%)
Control	0	0	0	0	100
KA	9.6±0.65	21.1±1.05	55.1±8.88	83	92
MB 0.5 mg/Kg+KA	9.9±0.49	27.4±1.14^*	112.1±5.35^*	17^*	100
MB 1 mg/Kg+KA	10.7±0.61	30.4±1.11^*	117.3±2.67^*	8^*	100
Vehicle+KA	9.7±0.62	23.4±0.91	55.18±8.85	83	92
^* P