Association of Single-Nucleotide Polymorphisms of Gab1 Gene with Susceptibility to Meningioma in a Northern Chinese Han Population

Weifeng Chen; Jiahui Zhao; Qianlan Wu; Hongshan Yan; Xiaoyan Wang; Chengrui Nan; Zhen Wu; Lei Chen; Zongmao Zhao

doi:10.12659/MSM.933444

04 November 2021: Lab/In Vitro Research

Association of Single-Nucleotide Polymorphisms of Gab1 Gene with Susceptibility to Meningioma in a Northern Chinese Han Population

Weifeng Chen ^12ABCEF* , Jiahui Zhao ^3ABC* , Qianlan Wu ^4BC* , Hongshan Yan ^1DF , Xiaoyan Wang ^1CD , Chengrui Nan ^1CD , Zhen Wu ^5FG , Lei Chen ^6FG , Zongmao Zhao ^1AEG*

DOI: 10.12659/MSM.933444

Med Sci Monit 2021; 27:e933444

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Table 3 Stratification analysis between Gab1 single-nucleotide polymorphisms and the clinical characteristics of meningioma.

Clinical characteristics (n)	rs3805246			rs3828512			rs3805236			rs1397529
Clinical characteristics (n)	GG	AG+GG	P	AA	AG+GG	P	AA	AG+GG	P	AA	AC	P
Tumor size (cm)
d ≤4.5 (109)	66	43	0.552	62	47	0.413	56	53	0.690	87	22	0.409
d >4.5 (96)	62	34	0.552	60	36	0.413	52	44	0.690	72	24	0.409
Location
Convexity (87)	51	36	1.559	48	39	2.807	41	46	1.894	63	24	2.385
Skull basis (66)	41	25		38	28		37	29		54	12
Others (52)	36	16		35	17		29	23		42	9
WHO grade
I (150)	97	53	0.277	92	58	0.380	79	71	0.994	115	35	0.612
II+III (55)	31	24	0.277	30	25	0.380	29	26	0.994	44	11	0.612
Peritumoral edema
Yes (120)	80	40	0.138	76	44	0.185	63	57	0.950	91	29	0.481
No (85)	48	37	0.138	46	39	0.185	45	40	0.950	68	17	0.481
Dural invasion
Yes (91)	59	32	0.527	56	35	0.597	49	42	0.766	64	27	0.027
No (114)	69	45	0.527	66	48	0.597	59	55	0.766	95	19	0.027

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Association of Single-Nucleotide Polymorphisms of Gab1 Gene with Susceptibility to Meningioma in a Northern Chinese Han Population

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