04 November 2021: Lab/In Vitro Research
Association of Single-Nucleotide Polymorphisms of Gab1 Gene with Susceptibility to Meningioma in a Northern Chinese Han Population
Weifeng Chen 12ABCEF* , Jiahui Zhao 3ABC* , Qianlan Wu 4BC* , Hongshan Yan 1DF , Xiaoyan Wang 1CD , Chengrui Nan 1CD , Zhen Wu 5FG , Lei Chen 6FG , Zongmao Zhao 1AEG*DOI: 10.12659/MSM.933444
Med Sci Monit 2021; 27:e933444
Table 2 Relationship of allele frequencies and genotype distribution of Gab1 single-nucleotide polymorphisms and the risk of meningioma.
| SNPs | Genetic model | Allele/genotype | Controls (n%) | Cases (n%) | P | OR (95% CI) | Pcorr | Adjusted OR (95% CI) |
|---|---|---|---|---|---|---|---|---|
| rs3805246 | G | 468 (78.8) | 312 (76.1) | 0.314 | 1.167 (0.864~1.575) | 0.258 | 1.190 (0.880~1.610) | |
| A | 126 (21.2) | 98 (23.9) | ||||||
| Codominant | GG | 189 (63.6) | 128 (62.4) | 0.216 | 1 (Reference) | 0.183 | 1 | |
| AG | 90 (30.3) | 56 (27.3) | 0.919 (0.615~1.373) | 0.931 (0.622~1.393) | ||||
| AA | 18 (6.1) | 21 (10.2) | 1.723 (0.883~3.361) | 1.799 (0.918~3.526) | ||||
| Dominant | GG | 189 (63.6) | 128 (62.4) | 0.785 | 1.053 (0.728~1.522) | 0.713 | 1.072 (0.740~1.553) | |
| AG+AA | 108 (36.4) | 77 (37.5) | ||||||
| Recessive | GG+AG | 279 (93.9) | 184 (89.8) | 0.089 | 0.565 (0.293~1.090) | 0.070 | 0.543 (0.281~1.052) | |
| AA | 18 (6.1) | 21 (10.2) | ||||||
| Overdominant | GG+AA | 207 (69.7) | 149 (72.7) | 0.469 | 1.157 (0.780~1.716) | 0.494 | 1.148 (0.773~1.706) | |
| AG | 90 (30.3) | 56 (27.3) | ||||||
| rs3828512 | A | 454 (76.4) | 304 (74.1) | 0.408 | 0.884 (0.661~1.183) | 0.334 | 0.866 (0.646~1.160) | |
| G | 140 (23.6) | 106 (25.9) | ||||||
| Codominant | AA | 179 (60.3) | 122 (59.5) | 0.314 | 1 (Reference) | 0.095 | 1 | |
| AG | 96 (32.3) | 60 (29.3) | 0.917 (0.617~1.363) | 0.946 (0.636~1.408) | ||||
| GG | 22 (7.4) | 23 (11.2) | 1.534 (0.818~2.875) | 2.002 (1.031~3.885) | ||||
| Dominant | AA | 179 (60.3) | 122 (59.5) | 0.865 | 1.032 (0.718~1.484) | 0.790 | 1.051 (0.729~1.513) | |
| AG+ GG | 118 (39.7) | 83 (40.5) | ||||||
| Recessive | AA+ AG | 275 (92.6) | 182 (88.8) | 0.144 | 1.580 (0.855~2.918) | 0.111 | 1.654 (0.891~3.071) | |
| GG | 22 (7.4) | 23 (11.2) | ||||||
| Overdominant | AA+ GG | 201 (61.7) | 145 (70.7) | 0.467 | 0.866 (0.588~1.276) | 0.481 | 0.870 (0.590~1.282) | |
| AG | 96 (32.3) | 60 (29.3) | ||||||
| rs3805236 | A | 470 (79.1) | 286 (69.8) | 0.001 | 1.643 (1.231~2.194) | 0.001 | 1.675 (1.252~2.240) | |
| G | 124 (20.9) | 124 (30.2) | ||||||
| Codominant | AA | 188 (63.3) | 108 (52.7) | 0.003 | 1 (Reference) | 0.002 | 1 | |
| AG | 94 (31.6) | 70 (34.1) | 1.296 (0.878~1.914) | 1.288 (0.871~1.906) | ||||
| GG | 15 (5.1) | 27 (13.2) | 3.133 (1.597~6.148) | 3.369 (1.704~6.661) | ||||
| Dominant | AA | 188 (63.3) | 108 (52.7) | 0.018 | 1.549 (1.079~2.224) | 0.016 | 1.561 (1.085~2.246) | |
| AG+GG | 109 (36.7) | 97 (47.3) | ||||||
| Recessive | AA+AG | 282 (94.9) | 15 (86.8) | 0.002 | 2.852 (1.476~5.509) | 0.001 | 3.074 (1.579~5.983) | |
| GG | 15 (5.1) | 27 (13.2) | ||||||
| Overdominant | AA+GG | 203 (68.4) | 135 (65.9) | 0.558 | 1.120 (0.767~1.635) | 0.609 | 1.104 (0.775~1.615) | |
| AG | 94 (31.6) | 70 (34.1) | ||||||
| rs1397529 | A | 552 (92.9) | 364 (88.8) | 0.023 | 0.602 (0.388~0.934) | 0.028 | 0.609 (0.392~0.947) | |
| C | 42 (7.1) | 46 (11.2) | ||||||
| Codominant | AA | 255 (85.9) | 159 (77.6) | 0.017 | 1.757 (1.106~2.790) | 0.020 | 1.737 (1.090~2.768) | |
| AC | 42 (14.1) | 46 (22.4) | ||||||
| OR – odds ratios; CI – confidence intervals; Adjusted OR – data was adjusted for gender and age; – corrected values by Bonferroni correction, adjusted by age and gender. | ||||||||