Evaluation of Susceptibility Genes/Loci Associated with Male Androgenetic Alopecia (MAGA) for Female-Pattern Hair Loss in a Chinese Han Population and a Brief Literature Review

Bo Liang; Yantao Ding; Yi Zhou; Chunjun Yang; Zhixiang Cheng

doi:10.12659/MSM.933424

10 November 2021: Clinical Research

Evaluation of Susceptibility Genes/Loci Associated with Male Androgenetic Alopecia (MAGA) for Female-Pattern Hair Loss in a Chinese Han Population and a Brief Literature Review

Bo Liang ^123AG* , Yantao Ding ^123B* , Yi Zhou ^123D* , Chunjun Yang ^4BF* , Zhixiang Cheng ^5FG*

DOI: 10.12659/MSM.933424

Med Sci Monit 2021; 27:e933424

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Table 1 Case-control association analysis for SNPs associated with MAGA in FPHL samples.

CHR	Locus	SNP	BP	Allele	Ref	OR (95% CI)	P*	FDR	Call-rate	Power (%)
1	1p36.22	rs12565727	11033082	G/A	[]¹¹	0.83 (0.58–1.19)	0.307	0.844	0.991	51
2	2q35	rs10193725	219726498	C/T	[]¹²	0.95 (0.67–1.35)	0.778	1.000	0.976	39
2	2q35	rs7349332	219756383	T/C		0.97 (0.65–1.42)	0.858	0.993	0.986	47
2	2q37.3	rs9752491	239734678	A/G	[]¹¹	0.59 (0.35–0.98)	0.041	0.902	0.983	29
2	2q37.3	rs9711321	239697444	C/T		1.40 (0.91–2.17)	0.126	0.924	0.971	29
2	2q37.3	rs12613833	239749411	C/T		0.88 (0.62–1.25)	0.485	0.667	0.976	48
3	3q25.1	rs4679955	151653368	T/A	[]¹²	1.16 (0.82–1.62)	0.406	0.687	0.981	26
5	5q33.3	rs929626	158310631	A/G		0.95 (0.66–1.36)	0.787	0.962	0.981	25
5	5q33.3	rs1081073	158381512	T/A		1.02 (0.72–1.44)	0.929	0.973	0.983	23
7	7p21.1	rs2249817	18862536	A/G	[]¹⁰	0.76 (0.53–1.09)	0.128	0.704	0.986	89
7	7p21.1	rs12056282	18848728	C/T		0.78 (0.47–1.30)	0.345	0.759	0.981	99
7	7p21.1	rs756853	18856525	A/G		0.85 (0.61–1.19)	0.356	0.653	0.985	95
7	7p21.1	rs13230142	18848034	A/G		0.82 (0.48–1.39)	0.454	0.666	0.983	100
7	7p21.1	rs17350355	18895028	A/G		1.00 (0.71–1.42)	0.98	0.980	0.983	21
12	12p12.1	rs7975017	26428793	T/C	[]¹²	1.22 (0.81–1.85)	0.346	0.692	0.981	23
12	12p12.1	rs9668810	26426420	C/T		0.87 (0.62–1.22)	0.426	0.669	0.988	32
18	18q12.3	rs10502861	42800148	T/C	[]¹¹	0.97 (0.61–1.55)	0.896	0.986	0.978	30
20	20p11	rs6137444	21733639	C/T	[]¹⁴	0.71 (0.49–1.02)	0.06	0.660	0.986	98
20	20p11	rs2180439	21801100	C/T		0.76 (0.54–1.09)	0.133	0.585	0.988	99
20	20p11	rs1998076	21828045	A/G		0.77 (0.54–1.10)	0.147	0.539	0.986	100
20	20p11	rs6113491	22005415	A/C		1.26 (0.89–1.77)	0.191	0.600	0.99	97
20	20p11	rs201571	21961514	T/C		1.18 (0.84–1.67)	0.334	0.816	0.986	98
BP – NCBI build 37; CI – confidence interval; OR – odds ratio. ^* P-values were calculated using the Armitage trend.

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Evaluation of Susceptibility Genes/Loci Associated with Male Androgenetic Alopecia (MAGA) for Female-Pattern Hair Loss in a Chinese Han Population and a Brief Literature Review

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