28 October 2021: Clinical Research
Adverse Side Effects Associated with Corticosteroid Therapy: A Study in 39 Patients with Generalized Myasthenia Gravis
Stephen Johnson 1ABCDEF , Nakul Katyal 2DEF , Naureen Narula 3DEF , Raghav Govindarajan 2ABCDEF*DOI: 10.12659/MSM.933296
Med Sci Monit 2021; 27:e933296
Table 1 Individual patient data.
| Patient no. | Age (years) | Sex | Race | Daily prednisone dose (mg)* | Side effect(s)** | Concomitant treatments for MG |
|---|---|---|---|---|---|---|
| 1 | 26 | F | W | 40 | Pre-diabetes, insomnia, acne, weight gain 40 lb | PS, MMF |
| 2 | 30 | F | W | 30 | Insomnia, acne, pedal edema | PS, MMF |
| 3 | 38 | F | W | 10 | Irritability | PS |
| 4 | 65 | F | W | 30 | Pre-diabetes, irritability | PS, Aza |
| 5 | 70 | M | W | 40 | Osteoporosis, insomnia | PS, MMF |
| 6 | 72 | F | W | 45 | Weight gain 30 lb | PS, MMF |
| 7 | 55 | M | W | 40 | Weight gain 35 lb, diabetes | PS, MMF, IVIg q4 weeks |
| 8 | 60 | M | W | 35 | Pre-diabetes, osteopenia | PS, Aza |
| 9 | 65 | M | W | 50 | Diabetes, osteoporosis | PS, MMF, IVIg q3 weeks |
| 10 | 62 | F | W | 30 | Insomnia, weight gain 20 lb, pedal edema | PS, MMF |
| 11 | 64 | F | W | 30 | Bruising, irritability | MMF |
| 12 | 50 | M | AA | 50 | Osteoporosis, bruises, pre-diabetes, recurrent infections | PS, MMF, IVIg q4 weeks |
| 13 | 20 | F | W | 20 | Weight gain 15 lb, acne, striae, bruises | PS, MMF |
| 14 | 24 | F | W | 30 | Insomnia, irritability, weight gain 15 lb | PS, MMF |
| 15 | 80 | M | W | 50 | Pedal edema, bruises, worsened diabetes requiring insulin | PS, MMF, IVIg q4 weeks |
| 16 | 26 | M | W | 40 | Pre-diabetes, weight gain 35 lb | MMF |
| 17 | 55 | M | W | 30 | Pre-diabetes | PS, MMF |
| 18 | 57 | F | W | 45 | Hypertension, weight gain 20 lb, pedal edema | PS, MMF |
| 19 | 67 | F | H | 35 | Bruising, pre-diabetes | PS, MMF |
| 20 | 68 | F | W | 40 | Recurrent upper respiratory tract infection, weight gain 40 lb | PS, MMF |
| 21 | 69 | M | W | 40 | Weight gain 35 lb | PS, MMF |
| 22 | 70 | M | W | 30 | Pre-diabetes | PS, MMF |
| 23 | 77 | M | W | 40 | Osteopenia, bruises | PS, MMF, IVIg q4 weeks |
| 24 | 68 | M | W | 35 | Pre-diabetes, insomnia | PS, MMF |
| 25 | 69 | F | W | 30 | Irritability, weight gain 20 lb | PS, MMF |
| 26 | 54 | M | AA | 50 | Pre-diabetes, weight gain 30 lb | PS, MMF |
| 27 | 43 | F | H | 30 | Weight gain 15 lb | PS, Aza |
| 28 | 58 | M | W | 40 | Pre-diabetes, osteopenia, pedal edema | PS, MMF |
| 29 | 60 | F | W | 40 | Pre-diabetes, osteopenia | PS, MMF |
| 30 | 64 | F | W | 30 | Pre-diabetes, osteopenia, insomnia, irritable mood | PS, MMF |
| 31 | 43 | F | W | 10 | Irritability, striae | PS |
| 32 | 48 | M | W | 15 | Pre-diabetes | PS |
| 33 | 54 | F | W | 30 | Pre-diabetes, pedal edema | PS, IVIg q4 weeks |
| 34 | 69 | M | W | 30 | Weight gain 20 lb, insomnia | PS, MMF |
| 35 | 72 | M | W | 50 | Osteoporosis, pedal edema | PS, MMF |
| 36 | 61 | F | W | 50 | Pre-diabetes, osteopenia, pedal edema | PS, MMF |
| 37 | 48 | F | W | 45 | Osteopenia, weight gain 35 lb | PS, MMF, IVIg q4 weeks |
| 38 | 78 | M | W | 50 | Pre-diabetes, bruises, osteoporosis, pedal edema, weight gain 20 lb, insomnia | PS, Aza |
| 39 | 59 | F | W | 40 | Weight gain 40 lb, recurrent skin infections, bruises | PS, MMF |
| * Based on the last recorded value in the patient’s medical charts; ** weight gain was rounded to the nearest 5 lb. AA – African-American; Aza – azathioprine; F – female; H – Hispanic; IVIg – intravenous immunoglobulin; M – male; PS – pyridostigmine; q – every; W – white. | ||||||