18 October 2021>: Lab/In Vitro Research
Salicylate Induced GABAR Internalization by Dopamine D1-Like Receptors Involving Protein Kinase C (PKC) in Spiral Ganglion Neurons
Jiangyuan Qin ABCDEF , Tingjia Wei BCD , Huiying Chen BCD , Xiaoyu Lin BC , Danxue Qin BC , Fangyu Wei BC , Peiqiang Liu BC , Wenhua Ye BC , Jiping Su ADG*DOI: 10.12659/MSM.933278
Med Sci Monit 2021; 27:e933278
Table 1 Drug treatment groups.
Inhibiting endocytosis | Inhibiting PKC |
---|---|
Ctrl | Ctrl |
SKF | SKF |
SKF+SCH | SKF+SCH |
Dynasore | Bis I |
SKF+Dynasore | SKF+Bis I |
SKF+SCH+Dynasore | SKF+SCH+Bis I |
SS | SS |
SS+SKF | SS+SKF |
SS+SKF+SCH | SS+SKF+SCH |
SS+Dynasore | SS+Bis I |
SS+SKF+Dynasore | SS+SKF+Bis I |
SS+SKF+SCH+Dynasore | SS+SKF+SCH+Bis I |
Ctrl – control; SKF – SKF38393, D1R agonist, 20 μM, MCE, USA; SCH – SCH23390, D1R antagonist, 20 μM, MCE, USA; Dynasore – clathrin/dynamin-mediated endocytosis inhibitor, 80 μM, Sigma, USA; SS – 5 mM, Sigma, USA; Bis I – Bisindolylmaleimide I, selective PKC antagonist, 4 μM, MCE, USA. |