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18 October 2021: Lab/In Vitro Research

Salicylate Induced GABAR Internalization by Dopamine D1-Like Receptors Involving Protein Kinase C (PKC) in Spiral Ganglion Neurons

Jiangyuan Qin ABCDEF , Tingjia Wei BCD , Huiying Chen BCD , Xiaoyu Lin BC , Danxue Qin BC , Fangyu Wei BC , Peiqiang Liu BC , Wenhua Ye BC , Jiping Su ADG*

DOI: 10.12659/MSM.933278

Med Sci Monit 2021; 27:e933278

Table 1 Drug treatment groups.

Inhibiting endocytosisInhibiting PKC
DynasoreBis I
SKF+DynasoreSKF+Bis I
SS+DynasoreSS+Bis I
SS+SKF+DynasoreSS+SKF+Bis I
Ctrl – control; SKF – SKF38393, D1R agonist, 20 μM, MCE, USA; SCH – SCH23390, D1R antagonist, 20 μM, MCE, USA; Dynasore – clathrin/dynamin-mediated endocytosis inhibitor, 80 μM, Sigma, USA; SS – 5 mM, Sigma, USA; Bis I – Bisindolylmaleimide I, selective PKC antagonist, 4 μM, MCE, USA.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750