Impact of Post-Mastectomy Radiation Therapy for Sentinel Lymph Node Micrometastases in Early-Stage Breast Cancer Patients

30 January 2022: Database Analysis

Hua Luo ^ACDEF** , Ou Ou Yang ^BCF* , Jun Ling He ^BCD , Tian Lan ^AD*

DOI: 10.12659/MSM.933275

Med Sci Monit 2022; 28:e933275

Table 3 Univariate and multivariate analyses of overall survival in unmatched and matched cohort.

Characteristics	Before PSM						After PSM
	5 year OS	Univariate		Multivariate			5 year OS	Univariate		Multivariate
	5 year OS	Chisq	P	HR	95%CI	P	5 year OS	Chisq	P	HR	95%CI	P
Age		50.288						8.045	0.005
	0.954			Reference			0.944			Reference
>50	0.879			2.03	1.48–2.78		0.918			1.39	0.87–2.22	0.168
Marital status		79.005						9.054	0.003
Married	0.938			Reference			0.942			Reference
Unmarried	0.84			2.22	1.78–2.77		0.896			1.48	0.98–2.22	0.061
Race		0.803	0.37					1.47	0.225
Non White	0.915			Reference			0.936			Reference
White	0.901			1.09	0.8–1.48	0.603	0.925			1.43	0.75–2.71	0.277
Median household income		8.782	0.032					12.242	0.007
Quartile 1	0.861			Reference			0.862			Reference
Quartile 2	0.919			0.87	0.7–1.07	0.197	0.931			0.64	0.44–0.94	0.022
Quartile 3	0.91			1.15	0.92–1.43	0.212	0.953			1.39	0.92–2.08	0.115
Quartile 4	0.92			0.86	0.68–1.08	0.188	0.954			0.86	0.55–1.34	0.503
T stage		25.135						15.59
T0/1	0.925			Reference			0.964			Reference
T2	0.876			1.69	1.35–2.11		0.897			2.78	1.79–4.31
Grade		17.861						7.583	0.006
I+II	0.917			Reference			0.94			Reference
III	0.867			1.44	1.12–1.84	0.005	0.899			1.37	0.87–2.16	0.169
ER status		25.656						21.061
Negative	0.788			Reference			0.785			Reference
Positive	0.919			0.77	0.54–1.09	0.141	0.946			0.44	0.22–0.87	0.018
PR status		45.864						16.306
Negative	0.814			Reference			0.858			Reference
Positive	0.928			0.60	0.44–0.8	0.001	0.947			0.66	0.37–1.17	0.154
Radiation		0.531	0.466					1.056	0.304
None/unknown	0.901			Reference			0.939			Reference
Yes	0.912			1.07	0.78–1.45	0.686	0.912			1.27	0.85–1.89	0.243
Chemotherapy		31.872						13.02
No/unknown	0.877			Reference			0.914			Reference
Yes	0.929			0.55	0.43–0.7		0.933			0.41	0.26–0.62
OS – overall survivall; PSM – propensity score matching; HR – hazard ratio; CI – confidence interval.