27 July 2021: Clinical Research
The Association Between Plasma α-Synuclein (α-syn) Protein, Urinary Alzheimer-Associated Neuronal Thread Protein (AD7c-NTP), and Apolipoprotein Epsilon 4 (ApoE ɛ4) Alleles and Cognitive Decline in 60 Patients with Alzheimer’s Disease Compared with 28 Age-Matched Normal Individuals
Shuang Lv 12BCDEF* , Xiao Zhou 23B* , Yiming Li 4BE , Shujuan Zhang 12BCD , Yu Wang 2F , Shuhong Jia 2D , Xiaoqian Niu 12B , Lei Wang 12B , Dantao Peng 123A*DOI: 10.12659/MSM.932998
Med Sci Monit 2021; 27:e932998
Table 1 Baseline characteristics of the AD and NC groups.
| AD (n=60) | NC (n=28) | P | |
|---|---|---|---|
| Age (years) | 70 (63, 77.5) | 71 (62.25, 76) | 0.989 |
| Male (%) | 20 (33.33%) | 10 (35.71%) | 0.826 |
| Education (years) | 11 (9,12) | 9 (6.75, 12) | 0.558 |
| Plasma α-syn (pg/mL) | 1879.16 (794.28, 4017.76) | 993.67 (728.11,1627.26) | 0.045 |
| Urine AD7c-NTP (ng/mL) | 0.90 (0.55, 1.74) | 0.61 (0.39, 1.05) | 0.017 |
| ApoE ɛ4 (%) | 15 (25%) | 4 (14.29%) | 0.255 |
| BMI (kg/cm) | 24.2 (21.26, 25.64) | 24.01 (21.02, 26.5) | 0.907 |
| Smoking (%) | 9 (15%) | 6 (21.43%) | 0.658 |
| Alcohol (%) | 9 (15%) | 2 (7.14%) | 0.489 |
| CHO (mmol/L) | 4.61 (4.08, 5.59) | 4.65 (4.21, 5.48) | 0.879 |
| HDL (mmol/L) | 1.35 (1.06, 1.66) | 1.38 (1.12, 1.75) | 0.479 |
| LDL (mmol/L) | 2.81 (2.39, 3.63) | 2.9 (2.47, 3.5) | 0.837 |
| TGs (mmol/L) | 1.35 (0.96, 1.95) | 1.03 (0.81, 1.57) | 0.109 |
| Baseline data are presented as the median and interquartile ranges (IQRs). Two-group comparisons, such as the analysis of differences in baseline characteristics between AD and NC, were analyzed by the independent-samples Mann-Whitney U test (unpaired). AD – Alzheimer’s disease; NC – normal control; SD – standard deviation; AD7c-NTP:– Alzheimer-associated neuronal thread protein; α-syn – α-synuclein; ApoE – apolipoprotein E; BMI – body mass index; CHO – cholesterol; HDL – high-density lipoproteins; LDL – low-density lipoprotein; TGs – triglycerides. | |||