Microarray Analysis of Differential Gene Expression Between Traumatic Temporomandibular Joint Fibrous and Bony Ankylosis in a Sheep Model

Tong-Mei Zhang; Kun Yang; Su-Xia Liang; Yuan-Yuan Tian; Zhao-Yuan Xu; Hao Liu; Ying-Bin Yan

doi:10.12659/MSM.932545

17 August 2021: Animal Study

Microarray Analysis of Differential Gene Expression Between Traumatic Temporomandibular Joint Fibrous and Bony Ankylosis in a Sheep Model

Tong-Mei Zhang ^1BCDEF* , Kun Yang ^2BCD* , Su-Xia Liang ^3AB , Pei-Pei Zhang ^4AB , Hua-Lun Wang ^1BD , Yuan-Yuan Tian ^1CD , Zhao-Yuan Xu ^1BC , Hao Liu ^1ABCDG* , Ying-Bin Yan ^1ABCDEFG*

DOI: 10.12659/MSM.932545

Med Sci Monit 2021; 27:e932545

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Table 2 Representative differentially expressed genes (DEGs) between fibrous and bony ankylosis.

Upregulated in FA at day 14		Upregulated in BA at day 14		Upregulated in FA at day 28		Upregulated in BA at day 28
Gene	Foldchange	Gene	Foldchange	Gene	Foldchange	Gene	Foldchange
PRG4	0.07	SYK	2.03	PRG4	0.05	BMP2	2.00
IL36B	0.22	FGR	2.05	MMP1	0.08	LRP4	2.00
NNAT	0.33	ITGAL	2.05	MMP3	0.11	CTGF	2.05
IL36A	0.34	ITGAM	2.07	RGS4	0.16	BMP4	2.18
ID1	0.38	CD86	2.10	BRB	0.18	IMPAD1	2.23
LYVE1	0.38	P2RY1	2.12	GPR1	0.20	FMOD	2.37
SLC38A4	0.40	FMNL1	2.15	PTHLH	0.22	TGFB2	2.38
SPIN4	0.42	ALCAM	2.20	STAC	0.22	TCF7	2.46
SLC7A2	0.43	SEMA4D	2.20	KYNU	0.23	SATB2	2.52
SFRP1	0.45	PRDM1	2.21	CDON	0.24	RUNX2	2.57
FANCG	0.46	CLEC7A	2.24	CCL21	0.24	SOX9	2.68
GRIA1	0.48	HSPA1A	2.26	STMN2	0.25	HHIP	2.93
PCDHGA2	0.48	CXCR4	2.35	OSR1	0.25	THBS4	2.98
CD8B	0.48	ATF3	2.36	RNASE6	0.26	CYR61	3.06
GSTCD	0.48	IL2RG	2.41	SERTM1	0.27	ITGA10	3.98
QPCT	0.48	PTPRC	2.42	FAM129A	0.27	ID1	4.15
ARHGEF9	0.48	TLR8	2.48	TMOD2	0.28	FGFR2	4.42
FGF13	0.49	CYBB	2.59	CCL23	0.29	FGFR3	5.18
GLI3	0.49	PIK3AP1	2.75	P2RY13	0.30	SP7	5.67
ZNF304	0.49	CLEC4D	3.13	NTN4	0.30	S100B	5.82
		IGSF6	3.19	GRIA1	0.30	TRPV4	6.70
		CCL4	3.34	LYVE1	0.31	SMOC2	7.08
		IL1R2	3.43	IL18	0.32	PTCH1	7.15
		NFKBIA	3.68	FGF10	0.34	ACAN	8.18
		KMO	3.75	TGFBR3	0.34	SERPINA1	8.41
		SLAMF6	4.80	TIAM1	0.34	MIA	9.08
		IGLV1–51	5.43	CD74	0.38	PTH1R	9.38
		VNN2	5.54	CXCL12	0.41	FRZB	9.62
		IGKV2–24	5.87	SLC7A2	0.41	PHOSPHO1	9.92
		JCHAIN	7.24	ITGB8	0.43	COL9A1	10.29
		LOC101119889	16.07	VEGFC	0.44	COL11A1	11.66
				VWF	0.44	SLC13A5	12.47
				CD44	0.44	LOC101119731	15.51
				FLT4	0.45	CHAD	24.65
				COL5A3	0.45	COMP	25.07
				CSF1R	0.46	APOD	26.65
				KDR	0.46	ALPL	28.79
				DQA	0.47	CLEC3A	32.86
				NRP1	0.48	HAPLN1	34.75
				CDH5	0.49	COL2A1	39.18
						OMD	42.87
						PANX3	45.14
						SCRG1	52.96
						COL10A1	70.25
						IBSP	268.53
FA – fibrous ankylosis; BA – bony ankylosis.

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Microarray Analysis of Differential Gene Expression Between Traumatic Temporomandibular Joint Fibrous and Bony Ankylosis in a Sheep Model

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