24 October 2021: Clinical Research
Vitamin D Receptor Is a Sepsis-Susceptibility Gene in Chinese Children
Danni He 12BCDEF* , Xiuxiu Lu 3ABCDEFG* , Wei Li 3BG , Yuanyuan Wang 4BD , Ning Li 3BC , Yuanmei Chen 2CEG , Lipeng Zhang 25EF , Wenquan Niu 1AEF* , Qi Zhang 2AEG*DOI: 10.12659/MSM.932518
Med Sci Monit 2021; 27:e932518
Table 4 Haplotype frequencies (>1% in all cases and controls) of variants in VDR genes between cases and controls, and haplotype-based risk prediction for sepsis mortality risk.
| Haplotype* | All | Cases | Controls | Hap-Score | P | Psim | OR (95% CI, P) |
|---|---|---|---|---|---|---|---|
| C-T-A-C-C-T-C-G-G | 0.44 | 0.46 | 0.41 | 2.16 | 0.03 | 0.04 | Ref. |
| A-T-A-T-C-T-C-A-G | 0.18 | 0.20 | 0.17 | 1.15 | 0.25 | 0.27 | 1.03 (0.70–1.50, 0.25) |
| C-C-C-C-G-T-C-G-G | 0.10 | 0.09 | 0.11 | −1.48 | 0.14 | 0.15 | 0.65 (0.41–1.02, 0.14) |
| C-C-C-C-C-T-C-G-G | 0.06 | 0.05 | 0.07 | −1.21 | 0.23 | 0.26 | 0.60 (0.33–1.12, 0.23) |
| C-T-C-C-C-T-C-G-G | 0.06 | 0.05 | 0.06 | −0.71 | 0.48 | 0.52 | 0.76 (0.42–1.36, 0.48) |
| A-C-C-T-C-T-C-A-G | 0.04 | 0.04 | 0.04 | −0.37 | 0.71 | 0.65 | 0.86 (0.41–1.81, 0.71) |
| C-C-C-C-C-T-C-A-G | 0.03 | 0.01 | 0.04 | −2.32 | 0.02 | 0.03 | 0.31 (0.12–0.76, 0.02) |
| C-C-A-C-C-T-C-G-G | 0.02 | 0.03 | 0.02 | 0.68 | 0.50 | 0.54 | 1.30 (0.51–3.33, 0.50) |
| A-T-C-T-C-T-C-A-G | 0.01 | 0.01 | 0.02 | −0.87 | 0.38 | 0.39 | 0.53 (0.11–2.62, 0.38) |
| Hap-Score – haplotype score, P – simulated value; OR – odds ratio; 95% CI – 95% confidence interval. * Alleles in each haplotype were in order of rs9729, rs2107301, rs2189480, rs2239185, rs3782905, rs4516035, rs7139166, rs11168266 and rs11168293 polymorphisms. | |||||||