24 October 2021: Clinical Research
Vitamin D Receptor Is a Sepsis-Susceptibility Gene in Chinese Children
Danni He 12BCDEF* , Xiuxiu Lu 3ABCDEFG* , Wei Li 3BG , Yuanyuan Wang 4BD , Ning Li 3BC , Yuanmei Chen 2CEG , Lipeng Zhang 25EF , Wenquan Niu 1AEF* , Qi Zhang 2AEG*DOI: 10.12659/MSM.932518
Med Sci Monit 2021; 27:e932518
Table 2 Genotype and allele distributions of VDR gene 9 studied variants between cases and controls, and genotype-based risk prediction for sepsis mortality risk.
| Variants | Cases (n=267) | Controls (n=283) | p Value | OR, 95% CI, p value | |
|---|---|---|---|---|---|
| rs9729 | CC | 133 (52%) | 144 (53%) | 0.98 | Reference group |
| AC | 104 (41%) | 112 (41%) | 1.05, 0.72–1.52, 0.81 | ||
| AA | 18 (7%) | 18 (6%) | 1.13, 0.55–2.31, 0.74 | ||
| A | 27% | 27% | 0.87 | ||
| rs2107301 | TT | 154 (59%) | 135 (48%) | 0.01 | Reference group |
| TC | 95 (36%) | 121 (43%) | 0.70, 0.48–1.01, 0.06 | ||
| CC | 12 (5%) | 26 (9%) | 0.44, 0.21–0.92, 0.03 | ||
| C | 23% | 31% | 0.003 | ||
| rs2189480 | AA | 137 (52%) | 109 (39%) | 0.004 | Reference group |
| CA | 106 (40%) | 137 (49%) | 0.62, 0.43–0.90, 0.01 | ||
| CC | 19 (8%) | 35 (12%) | 0.43, 0.23–0.81, 0.009 | ||
| C | 27% | 37% | 0.001 | ||
| rs2239185 | CC | 135 (51%) | 154 (55%) | 0.32 | Reference group |
| CT | 108 (41%) | 115 (41%) | 1.11, 0.77–1.59, 0.59 | ||
| TT | 20 (8%) | 13 (5%) | 1.94, 0.91–4.14, 0.09 | ||
| T | 28% | 25% | 0.24 | ||
| rs3782905 | CC | 192 (80%) | 195 (75%) | 0.20 | Reference group |
| CG | 48 (20%) | 60 (23%) | 0.83, 0.53–1.31, 0.43 | ||
| GG | 1 (0.4%) | 5 (2%) | 0.26, 0.03–2.39, 0.23 | ||
| G | 11% | 13% | 0.13 | ||
| rs4516035 | TT | 249 (95%) | 267 (96%) | 0.41 | Reference group |
| CT | 14 (5%) | 10 (4%) | 1.62, 0.66–3.94, 0.29 | ||
| CC | 0 (0%) | 1 (0.4%) | Unavailable | ||
| C | 3% | 2% | 0.59 | ||
| rs7139166 | CC | 248 (95%) | 271 (96%) | 0.54 | Reference group |
| CG | 14 (5%) | 11 (4%) | 1.52, 0.64–3.63, 0.35 | ||
| GG | 0 (0%) | 1 (0.4%) | Unavailable | ||
| G | 3% | 2% | 0.69 | ||
| rs11168266 | GG | 135 (52%) | 149 (53%) | 0.72 | Reference group |
| GA | 104 (40%) | 105 (38%) | 1.15, 0.79–1.68, 0.45 | ||
| AA | 20 (8%) | 26 (9%) | 0.89, 0.46–1.70, 0.72 | ||
| A | 28% | 28% | |||
| rs11168293 | GG | 250 (96.53%) | 272 (96.80%) | 0.86 | Reference group |
| GT | 9 (3%) | 9 (3%) | 1.24, 0.46–3.35, 0.68 | ||
| TT | 0 (0%) | 0 (0%) | Unavailable | ||
| T | 3% | 3% | 0.93 | ||
| OR – odds ratio; 95% CI – 95% confidence interval. The values were calculated after adjusting for age and sex in a logistic regression analysis. | |||||