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21 October 2021: Clinical Research

Integrating Intrinsic Radiosensitivity and Immune Status for Predicting Benefits of Radiotherapy in Head and Neck Squamous Cell Carcinoma

Chuyao Sun 12ADE , Miao Zhang 1BCF , Qiao Qiao 1ADE , Yanli Wang 1C*

DOI: 10.12659/MSM.932126

Med Sci Monit 2021; 27:e932126

Table 4 Univariate and multivariate Cox regression analyses of interaction between RSS (as continues variable) and RT in training and validation cohort.

VariablesUnivariateMultivariate
HR (95% CI)P valueHR (95% CI)P value
RSI * RT0.650 (0.393–1.074)0.093
Immune score * RT0.999 (0.999–1.000)0.0040.999 (0.999–1.000)0.249
RSS * RT2.873 (1.431–5.769)0.0033.367 (1.323–8.565)0.011
Clinical stage * RT0.980 (0.899–1.068)0.638
Neoplasm histologic grade * RT0.956 (0.832–1.099)0.527
Lymphovascular invasion * RT1.233 (0.920–1.636)0.146
Margin status * RT1.401 (1.055–1.861)0.0200.982 (0.679–1.420)0.923
Pathological nodal extra-capsular * RT1.720 (1.324–2.234)4.83e–051.953 (1.466–2.603)4.8e–06
RSI * RT0.588 (0.304–1.139)0.166
Immune score * RT1.000 (0.999–1.000)0.671
RSS * RT3.109 (1.216–7.952)0.0183.073 (1.004–9.406)0.049
Clinical stage * RT0.919 (0.829–1.019)0.110
Neoplasm histologic grade * RT0.923 (0.775–1.099)0.367
Lymphovascular invasion * RT0.936 (0.639–1.371)0.735
Margin status * RT0.863 (0.568–1.312)0.492
Pathological nodal extra-capsular * RT1.527 (1.104–2.111)0.0111.534 (1.110–2.119)0.010
RT – radiotherapy; RSI – radiosensitivity index; RSS – radiosensitivity signature; HR – hazard ratio; 95% CI – 95% confidence interval.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750