02 October 2021: Clinical Research
Preoperative Alkaline Phosphatase-to-Cholesterol Ratio as a Predictor of Overall Survival in Pancreatic Ductal Adenocarcinoma Patients Undergoing Radical Pancreaticoduodenectomy
Guotong Qiu ABCDEF , Lipeng Zhang BD , Zongting Gu CD , Hu Ren BC , Yongxing Du DF , Zongze Li B , Chengfeng Wang DFG*DOI: 10.12659/MSM.931868
Med Sci Monit 2021; 27:e931868
Table 4 Multivariate analysis for overall survival in pancreatic ductal adenocarcinoma patients who underwent radical pancreaticoduodenectomy.
| Variables | Categories | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|---|
| Wald | P | HR (95.0% CI) | Wald | P | HR (95.0% CI) | ||
| Gender | Male vs Female | 6.558 | 0.01 | 1.763 (1.142–2.72) | 5.644 | 0.018 | 1.725 (1.1–2.704) |
| White blood cell (10/l) | >4.33 vs ≤4.33 | 6.85 | 0.009 | 2.541 (1.264–5.109) | / | ||
| Alanine aminotransferase (U/l) | >15.55 vs ≤15.55 | 7.297 | 0.007 | 3.169 (1.372–7.317) | / | ||
| Total bilirubin (umol/l) | >141.4 vs ≤141.4 | 9.831 | 0.002 | 2.071 (1.314–3.266) | / | ||
| Carbohydrate antigen 19-9 (U/ml) | >117.95 vs ≤117.95 | 7.777 | 0.005 | 2.043 (1.236–3.375) | / | ||
| Degree of differentiation | 14.186 | 0.0001 | |||||
| Poorly/well | 15.974 | 0.0001 | 15.113 (3.99–57.239) | 11.128 | 0.001 | 14.724 (3.032–71.494) | |
| Moderately/well | 6.61 | 0.01 | 4.6 (1.437–14.724) | 4.893 | 0.027 | 5.074 (1.203–21.398) | |
| Adjuvant therapy | Absent vs present | 3.989 | 0.046 | 1.55 (1.008–2.384) | / | ||
| Preoperative plasma ALP (U/l) | >108.5 vs ≤108.5 | 8.899 | 0.003 | 2.247 (1.32–3.824) | / | ||
| Preoperative plasma CHO (mmol/l) | >3.49 vs ≤3.49 | 1.762 | 0.184 | 0.691 (0.4–1.193) | / | ||
| Preoperative ACR | >32.988 vs ≤32.988 | 13.796 | 0.0001 | 2.609 (1.573–4.327) | 9.273 | 0.002 | 2.225 (1.33–3.724) |
| HR – hazard ratio; CI – confidence interval; ALP – alkaline phosphatase; CHO – cholesterol ratio; ACR – alkaline phosphatase/cholesterol ratio. | |||||||