02 October 2021>: Clinical Research
Preoperative Alkaline Phosphatase-to-Cholesterol Ratio as a Predictor of Overall Survival in Pancreatic Ductal Adenocarcinoma Patients Undergoing Radical Pancreaticoduodenectomy
Guotong Qiu ABCDEF , Lipeng Zhang BD , Zongting Gu CD , Hu Ren BC , Yongxing Du DF , Zongze Li B , Chengfeng Wang DFG*DOI: 10.12659/MSM.931868
Med Sci Monit 2021; 27:e931868
Table 2 Correlation between preoperative alkaline phosphatase-to-cholesterol ratio (ACR) and clinicopathological characteristics in pancreatic ductal adenocarcinoma patients who underwent radical pancreaticoduodenectomy, n (%).
Characteristic | Preoperative ACR | P value | |
---|---|---|---|
>32.988 (n=68) | ≤32.988 (n=34) | ||
Age (year) | 0.888 | ||
>60 | 29 (28.4) | 15 (14.7) | |
≤60 | 39 (38.2) | 19 (18.6) | |
Sex | 0.482 | ||
Male | 33 (32.4) | 14 (13.7) | |
Female | 35 (34.3) | 20 (19.6) | |
Body mass index (kg/m) | 0.416 | ||
>26.8 | 8 (7.8) | 6 (5.9) | |
≤26.8 | 60 (58.8) | 28 (27.5) | |
White blood cell (10/l) | 0.124 | ||
>4.33 | 60 (58.8) | 26 (25.5) | |
≤4.33 | 8 (7.8) | 8 (7.8) | |
Alanine aminotransferase (U/l) | 0.001 | ||
>15.55 | 66 (64.7) | 23 (22.5) | |
≤15.55 | 2 (2.0) | 11 (10.8) | |
Aspartate aminotransferase (U/l) | 0.001 | ||
>25.5 | 61 (59.8) | 13 (12.7) | |
≤25.5 | 7 (6.9) | 21 (20.6) | |
Total bilirubin (umol/l) | 0.001 | ||
>141.4 | 33 (32.4) | 2 (2.0) | |
≤141.4 | 35 (34.3) | 32 (31.4) | |
Albumin (g/l) | 0.05 | ||
>40.55 | 30 (29.4) | 22 (21.6) | |
≤40.55 | 38 (37.3) | 12 (11.8) | |
Globulin (g/l) | 0.119 | ||
>25.05 | 43 (42.2) | 16 (15.7) | |
≤25.05 | 25 (24.5) | 18 (17.6) | |
Carbohydrate antigen 19-9 (U/ml) | 0.016 | ||
>117.95 | 52 (51) | 18 (17.6) | |
≤117.95 | 16 (15.7) | 16 (15.7) | |
Clinical symptoms | 0.001 | ||
Absent | 3 (2.9) | 11 (10.8) | |
Present | 65 (63.7) | 23 (22.5) | |
Diabetes | 0.634 | ||
Absent | 49 (48) | 26 (25.5) | |
Present | 19 (18.6) | 8 (7.8) | |
Hypertension | 0.603 | ||
Absent | 53 (52.0) | 28 (27.5) | |
Present | 15 (14.7) | 6 (5.9) | |
Smoking status | 0.748 | ||
Absent | 50 (49.0) | 26 (25.5) | |
Present | 18 (17.6) | 8 (7.8) | |
Alcohol consumption | 0.851 | ||
Absent | 57 (55.9) | 28 (27.5) | |
Present | 11 (10.8) | 6 (5.9) | |
Family history of cancer | 0.214 | ||
Absent | 67 (65.7) | 32 (31.4) | |
Present | 1 (1.0) | 2 (2) | |
ASA | 0.145 | ||
1 | 1 (1.0) | 1 (1.0) | |
2 | 53 (52) | 31 (30.4) | |
3 | 14 (13.7) | 2 (2.0) | |
Degree of differentiation | 0.018 | ||
Poorly | 9 (8.8) | 2 (2.0) | |
Moderately | 58 (56.9) | 27 (26.5) | |
Well | 1 (1.0) | 5 (4.9) | |
Lymphovascular invasion | 0.467 | ||
Absent | 45 (44.1) | 20 (19.6) | |
Present | 23 (22.5) | 14 (13.7) | |
Perineural invasion | 0.86 | ||
Absent | 13 (12.7) | 7 (6.9) | |
Present | 55 (53.9) | 27 (26.5) | |
Capsular invasion | 0.167 | ||
Absent | 17 (16.7) | 13 (12.7) | |
Present | 51 (50) | 21 (20.6) | |
Maximum tumor diameter (cm) | 0.416 | ||
>4 | 8 (7.8) | 6 (5.9) | |
≤4 | 60 (58.8) | 28 (27.5) | |
T stage | 0.293 | ||
T1 | 8 (7.8) | 7 (6.9) | |
T2 | 52 (51.0) | 21 (20.6) | |
T3 | 8 (7.8) | 6 (5.9) | |
N stage | 0.148 | ||
N0 | 34 (33.3) | 19 (18.6) | |
N1 | 20 (19.6) | 13 (12.7) | |
N2 | 14 (13.7) | 2 (2.0) | |
TNM stage | 0.148 | ||
1 | 25 (24.5) | 16 (15.7) | |
2 | 29 (28.4) | 16 (15.7) | |
3 | 14 (13.7) | 2 (2.0) | |
Adjuvant therapy | 0.07 | ||
Absent | 37 (36.3) | 12 (11.8) | |
Present | 31 (30.4) | 22 (21.6) | |
Preoperative plasma alkaline phosphatase (U/l) | 0.001 | ||
>108.5 | 66 (64.7) | 6 (5.9) | |
≤108.5 | 2 (2.0) | 28 (27.5) | |
Preoperative plasma cholesterol (mmol/l) | 0.061 | ||
>3.49 | 57 (55.9) | 23 (22.5) | |
≤3.49 | 11 (10.8) | 11 (10.8) | |
ACR – alkaline phosphatase/cholesterol ratio. |