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02 October 2021: Clinical Research

Preoperative Alkaline Phosphatase-to-Cholesterol Ratio as a Predictor of Overall Survival in Pancreatic Ductal Adenocarcinoma Patients Undergoing Radical Pancreaticoduodenectomy

Guotong Qiu ABCDEF , Lipeng Zhang BD , Zongting Gu CD , Hu Ren BC , Yongxing Du DF , Zongze Li B , Chengfeng Wang DFG*

DOI: 10.12659/MSM.931868

Med Sci Monit 2021; 27:e931868

Table 1 Baseline characteristics of 102 pancreatic ductal adenocarcinoma patients who underwent radical pancreaticoduodenectomy, n (%).

CharacteristicPatients (n=102)
Age (year)59 (31–77)
 >6044 (43.1)
 ≤6058 (56.9)
Sex
 Male47 (46.8)
 Female55 (53.9)
Body mass index (kg/m)22.3 (17.4–31.9)
 >26.814 (13.7)
 ≤26.888 (86.3)
White blood cell (10/L)5.7 (2.8–25.8)
 >4.3386 (84.3)
 ≤4.3316 (15.7)
Alanine aminotransferase (U/L)68.5 (9.0–805.0)
 >15.5589 (87.3)
 ≤15.5513 (12.7)
Aspartate aminotransferase (U/L)53 (10.0–868.0)
 >25.574 (72.5)
 ≤25.528 (27.5)
Total bilirubin (umol/L)59.8 (3.6–419.5)
 >141.435 (34.3)
 ≤141.467 (65.7)
Albumin (g/L)40.6 (23.2–53.1)
 >40.5552 (50.8)
 ≤40.5550 (49.2)
Globulin (g/L)25.3 (1.9–209.0)
 >25.0559 (57.8)
 ≤25.0543 (42.2)
Carbohydrate antigen 19-9 (U/ml)189.5 (1.0–4839.0)
 >117.9570 (68.6)
 ≤117.9532 (31.4)
Clinical symptoms
 Absent14 (13.7)
 Present88 (86.3)
Diabetes
 Absent75 (73.5)
 Present27 (26.5)
Hypertension
 Absent81 (79.4)
 Present21 (20.6)
Smoking status
 Absent69 (67.6)
 Present33 (32.4)
Alcohol consumption
 Absent76 (74.6)
 Present16 (15.7)
Family history of cancer
 Absent99 (97.1)
 Present3 (2.9)
ASA
 12 (2.0)
 284 (82.4)
 316 (15.7)
Degree of differentiation
 Poorly11 (10.8)
 Moderately85 (83.3)
 Well6 (5.9)
Lymphovascular invasion
 Absent65 (63.7)
 Present37 (36.3)
Perineural invasion
 Absent20 (19.6)
 Present82 (80.4)
Capsular invasion
 Absent30 (29.4)
 Present72 (70.6)
Maximum tumor diameter (cm)
 >414 (13.7)
 ≤488 (86.3)
T stage
 T115 (14.7)
 T273 (71.6)
 T314 (13.7)
N stage
 N053 (52)
 N133 (32.4)
 N216 (15.7)
TNM stage
 141 (40.2)
 245 (44.1)
 316 (15.7)
Adjuvant therapy
 Absent49 (48)
 Present53 (52)
Preoperative plasma alkaline phosphatase (U/L)207.0 (43.0–1385.0)
 >108.572 (70.6)
 ≤108.530 (29.4)
Preoperative plasma cholesterol (mmol/L)4.7 (2.3–12.5)
 >3.4980 (78.4)
 ≤3.4922 (21.6)
Preoperative ACR45.0 (9.0–325.9)
 >32.98868 (66.7)
 ≤32.98834 (33.3)
ACR – alkaline phosphatase/cholesterol ratio.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750