25 August 2021: Clinical Research
“Obesity Paradox” in Acute Respiratory Distress Syndrome Among Patients Undergoing Cardiac Surgery: A Retrospective Study
Yan Liu 1ABCDEFG , Man Song 1BCDF , Lixue Huang 2BCDF , Guangfa Zhu 13ACG*DOI: 10.12659/MSM.931808
Med Sci Monit 2021; 27:e931808
Supplementary Table 4 Univariate analysis for mortality of acute respiratory distress syndrome.
| Covariate | Statistics | HR (95% CI) | P value |
|---|---|---|---|
| BMI | 24.31±3.99 | 0.89 (0.82, 0.96) | 0.003 |
| Age, years | 58.32±13.64 | 0.98 (0.95, 1.00) | 0.038 |
| Smoking index | 500.00 (400.00–800.00) | 1.00 (1.00, 1.00) | 0.320 |
| EF value before surgery, % | 50.01±25.03 | 0.99 (0.98, 1.00) | 0.129 |
| Hemoglobin level before surgery, g/l | 123.94±23.41 | 0.99 (0.97, 1.00) | 0.049 |
| Albumin level before surgery, g/l | 37.61±8.63 | 1.02 (0.99, 1.06) | 0.177 |
| APACHE II value | 19.70±5.74 | 1.00 (0.95, 1.05) | 0.949 |
| Duration of surgery, hours | 6.34±2.76 | 1.10 (0.98, 1.24) | 0.093 |
| Blood loss, ml | 1000.00 (600.00–1500.00) | 1.00 (1.00, 1.00) | 0.374 |
| Transfusion of red blood cells, ml | 750.00 (400.00–1200.00) | 1.00 (1.00, 1.00) | 0.651 |
| Transfusion of plasma cells, ml | 200.00 (0.00–400.00) | 1.00 (1.00, 1.00) | 0.089 |
| EF value after surgery, % | 50.01±25.03 | 0.99 (0.98, 1.00) | 0.129 |
| Duration of incubation time, hours | 209.43±233.70 | 1.00 (1.00, 1.00) | 0.470 |
| Gender, % | 0.266 | ||
| Male | 132 (65.35%) | 1.0 | |
| Female | 70 (34.65%) | 1.43 (0.76, 2.68) | |
| History of cardiac surgery, % | 0.846 | ||
| No | 180 (89.11%) | 1.0 | |
| Yes | 22 (10.89%) | 1.10 (0.43, 2.84) | |
| History of hypertension, % | 0.555 | ||
| No | 95 (47.03%) | 1.0 | |
| Yes | 107 (52.97%) | 0.84 (0.47, 1.51) | |
| History of diabetes, % | 0.022 | ||
| No | 156 (77.23%) | 1.0 | |
| Yes | 46 (22.77%) | 0.46 (0.23, 0.89) | |
| History of AMI, % | 0.385 | ||
| No | 153 (75.74%) | 1.0 | |
| Yes | 49 (24.26%) | 0.74 (0.38, 1.45) | |
| Emergency surgery, % | 0.382 | ||
| No | 172 (85.15%) | 1.0 | |
| Yes | 30 (14.85%) | 1.47 (0.62, 3.51) | |
| Type of surgery, % | |||
| Isolated valvular surgery or isolated CABG surgery | 104 (51.49%) | 1.0 | - |
| Valvular combined with CABG surgery | 29 (14.36%) | 0.98 (0.42, 2.29) | 0.966 |
| Aortic surgery | 37 (18.32%) | 1.62 (0.71, 3.70) | 0.253 |
| Others | 32 (15.84%) | 1.80 (0.74, 4.40) | 0.197 |
| Infection after surgery | 0.741 | ||
| No | 125 (61.88%) | 1.0 | |
| Yes | 77 (38.12%) | 0.90 (0.50, 1.64) | |
| IABP after surgery | 0.514 | ||
| No | 158 (78.22%) | 1.0 | |
| Yes | 44 (21.78%) | 1.27 (0.62, 2.63) | |
| ECMO after surgery | 0.146 | ||
| No | 174 (86.14%) | 1.0 | |
| Yes | 28 (13.86%) | 2.03 (0.78, 5.27) | |
| CRRT after surgery | 0.308 | ||
| No | 136 (67.33%) | 1.0 | |
| Yes | 66 (32.67%) | 1.39 (0.74, 2.64) | |
| Tracheotomy after surgery | 0.779 | ||
| No | 137 (67.82%) | 1.0 | |
| Yes | 65 (32.18%) | 1.09 (0.58, 2.05) | |
| Second intubation after surgery | 0.002 | ||
| No | 88 (43.56%) | 1.0 | |
| Yes | 114 (56.44%) | 2.56 (1.41, 4.66) | |
| EF – ejection fraction; COPD – chronic obstructive pulmonary disease; AMI - acute myocardial infarction; CABG – coronary artery bypass grafting; APACHE – acute physiology and chronic health evaluation; ARDS – acute respiratory distress syndrome; IABP – intra-aortic balloon pump; ECMO – extracorporeal membrane oxygenation therapy; CRRT – continuous renal replacement therapy. | |||