25 July 2021>: Animal Study
Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) and Treadmill Training on Recovery of Motor Function in a Rat Model of Partial Spinal Cord Injury
Pei Wang 12CDE , Ruian Yin 1B , Shuangyan Wang 1BC , Ting Zhou 3B , Yongjie Zhang 4D , Ming Xiao 5D , Hongxing Wang 23AFG* , Guangxu Xu 1AFG*DOI: 10.12659/MSM.931601
Med Sci Monit 2021; 27:e931601
Table 2 IHC and WB.
Tissues | Methods | Measures | Intact | S-rTMS/Non-TT | S-rTMS/TT | rTMS/Non-TT | rTMS/TT |
---|---|---|---|---|---|---|---|
Motor cortex | IHC | BDNF | 100.00± 15.08%** | 90.30± 18.00%,# | 110.65± 4.95%* | 127.49± 13.26% | 145.81± 18.88% |
SYN | 100.00± 6.82% | 93.03± 4.50%** | 101.36± 11.07% | 109.62± 9.62% | 115.65± 4.93% | ||
PSD-95 | 100.00± 7.32%** | 88.05± 7.40%,## | 104.60± 8.85%* | 114.56± 7.01% | 122.00± 8.21% | ||
WB | BDNF | 100.00± 27.19%*** | 82.67± 22.59%,# | 170.77± 31.81%* | 195.51± 53.88% | 300.35± 87.44% | |
SYN | 100.00± 36.73% | 86.95± 27.29%* | 136.13± 47.51% | 146.29± 44.11% | 178.91± 48.27% | ||
PSD-95 | 100.00± 11.66%** | 77.03± 16.43%,# | 131.23± 31.74%* | 137.00± 29.49% | 194.33± 37.98% | ||
Spinal cord | IHC | BDNF | 100.00± 7.14%*** | 82.71± 8.18%,,& | 115.18± 5.76%** | 98.58± 8.03%*** | 143.75± 8.72% |
SYN | 100.00± 8.53% | 84.06± 9.75%** | 102.06± 6.46% | 98.49± 8.49% | 118.34± 12.33% | ||
PSD-95 | 100.00± 8.86% | 93.11± 8.57%* | 110.16± 8.05% | 106.95± 9.36% | 117.68± 10.12% | ||
WB | BDNF | 100.00± 23.17%*** | 34.52± 3.88%,,& | 155.47± 21.91%* | 95.24± 24.99%*** | 225.52± 47.22% | |
SYN | 100.00± 23.45% | 66.98± 29.71%* | 109.21± 36.51% | 87.96± 29.06% | 137.78± 38.33% | ||
PSD-95 | 100.00± 23.52% | 72.73± 35.31%* | 131.24± 42.86% | 101.39± 23.98% | 163.87± 45.26% | ||
* ** *** # ## & &&& Data presented as mean ± standard deviation. IHC – immunohistochemistry; WB – western blotting; BDNF, brain-derived neurotrophic factor; SYN – synapsin I; PSD-95 – postsynaptic density protein-95; rTMS – repetitive transcranial magnetic stimulation; TT – treadmill training; S – sham. |