25 July 2021>: Animal Study
Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) and Treadmill Training on Recovery of Motor Function in a Rat Model of Partial Spinal Cord Injury
Pei Wang 12CDE , Ruian Yin 1B , Shuangyan Wang 1BC , Ting Zhou 3B , Yongjie Zhang 4D , Ming Xiao 5D , Hongxing Wang 23AFG* , Guangxu Xu 1AFG*DOI: 10.12659/MSM.931601
Med Sci Monit 2021; 27:e931601
Table 1 Motor function assessment.
Behavioral tests | Time | Intact | S-rTMS/Non-TT | S-rTMS/TT | rTMS/Non-TT | rTMS/TT |
---|---|---|---|---|---|---|
Basso, Beattie, and Bresnahan scores | Baseline | 21 | 21 | 21 | 21 | 21 |
1D | 21 | 0.21±0.41 | 0.21±0.41 | 0.25±0.44 | 0.29±0.46 | |
1W | 21 | 6.79±2.26 | 6.67±1.97 | 6.38±2.60 | 6.67±2.08 | |
2W | 21 | 9.29±1.83 | 8.92±1.44 | 9.04±1.97 | 9.58±1.84 | |
3W | 21 | 11.04±1.81 | 11.50±1.79 | 11.17±2.53 | 11.79±2.43 | |
4W | 21 | 11.92±1.93 | 12.29±1.92 | 12.08±2.45 | 12.50±2.36 | |
5W | 21 | 12.63±1.53 | 13.04±1.90 | 12.88±2.49 | 13.42±2.24 | |
6W | 21 | 13.17±1.55 | 13.46±1.93 | 13.46±2.30 | 14.04±2.10 | |
7W | 21 | 13.32±1.64** | 13.92±2.00 | 13.71±2.24* | 14.79±1.96 | |
8W | 21 | 13.77±1.77** | 14.25±2.03* | 14.17±2.33* | 15.25±1.94 | |
9W | 21 | 13.77±1.77** | 14.42±1.98* | 14.29±2.27* | 15.85±1.93 | |
Grid walking test (foot drops) | Baseline | 2.58±1.31 | 2.58±1.08 | 2.42±0.90 | 2.58±1.31 | 2.50±1.17 |
9W | 2.75±1.36 | 26.82±4.09,### | 25.75±3.41### | 26.17±4.41### | 22.08±4.06### | |
* ** ### Data presented as mean±standard deviation. rTMS – repetitive transcranial magnetic stimulation; TT – treadmill training; S – sham; D – day; W – week. |