Intermittent Theta Burst Stimulation (iTBS) for Treatment of Chronic Post-Stroke Aphasia: Results of a Pilot Randomized, Double-Blind, Sham-Controlled Trial

Jerzy P. Szaflarski; Rodolphe Nenert; Jane B. Allendorfer; Amber N. Martin; Amy W. Amara; Joseph C. Griffis; Aimee Dietz; Victor W. Mark; Victor W. Sung; Harrison C. Walker; Xiaohua Zhou; Christopher J. Lindsell

doi:10.12659/MSM.931468

29 June 2021: Clinical Research

Intermittent Theta Burst Stimulation (iTBS) for Treatment of Chronic Post-Stroke Aphasia: Results of a Pilot Randomized, Double-Blind, Sham-Controlled Trial

Jerzy P. Szaflarski ^12ABDEFG* , Rodolphe Nenert ^1BCDE , Jane B. Allendorfer ^13BE , Amber N. Martin ^1BE , Amy W. Amara ^13BE , Joseph C. Griffis ^14BE* , Aimee Dietz ^5AE , Victor W. Mark ^146DE , Victor W. Sung ^1BE , Harrison C. Walker ^16BE , Xiaohua Zhou ^6BE , Christopher J. Lindsell ^7ACE

DOI: 10.12659/MSM.931468

Med Sci Monit 2021; 27:e931468

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Table 4 Main peak MNI coordinates (x, y, z) for significant results of gPPI connectivity analysis. For each participant, the first principal component of the BOLD time series from each scan was extracted from the right and left inferior frontal gyrus (IFG) and entered as a seed time series for the gPPI analysis.

Left IFG						Right IFG
Group/time	Region label	t-value	MNI coordinates			Group/time	Region label	t-value	MNI coordinates
Group/time	Region label	t-value	x	y	z	Group/time	Region label	t-value	x	y	z
G0/t1>t5	SupraMarginal_R	49.1	52	−32	36	G0/t1>t5	Postcentral_R	28.7	14	−34	62
	Occipital_Mid_R	26.5	38	−70	38		Paracentral_Lobule_L	21.7	−4	−30	58
	Angular_R	17.3	38	−66	40		Paracentral_Lobule_R	20.0	10	−30	52
G0/t2>t5	Frontal_Inf_Tri_R	14.2	44	28	24		Precentral_R	17.7	16	−30	66
G0/t2>t5	Frontal_Inf_Oper_R	11.8	38	8	28	G1/t5>t1	Precentral_L	89.7	−32	−4	42
G1/t5>t1	Parietal_Sup_L	125.3	−28	−54	64		Angular_L	73.6	−42	−58	30
	Precuneus_L	64.4	−8	−58	38		Parietal_Inf_L	66.1	−32	−46	54
	Paracentral_Lobule_R	111.2	10	−38	58		Postcentral_L	36.7	−34	−38	50
	Angular_R	103.5	34	−62	42		Lingual_R	51.0	14	−30	−12
	Cingulate_Post_L	20.9	−6	−38	16		Vermis_3	25.5	4	−36	−8
	Parietal_Sup_R	52.0	22	−58	58		Temporal_Sup_L	49.4	−54	−20	12
	Cuneus_R	50.5	16	−68	34		Heschl_L	47.5	−40	−24	12
	Precuneus_R	24.0	12	−60	30		Calcarine_L	38.8	−16	−50	8
	Caudate_R	34.8	12	18	10		Precuneus_L	13.0	−8	−54	10
	Temporal_Sup_R	23.2	48	−56	22		Cingulate_Post_L	10.9	−14	−44	8
	Temporal_Mid_R	12.2	48	−62	18		Rolandic_Oper_R	27.4	48	−2	6
G2/t4>t5	Occipital_Mid_L	75.8	−38	−64	22	G2/t5>t1	Lingual_L	33.7	−16	−72	−4
	Temporal_Mid_L	23.4	−40	−66	20
	Lingual_L	32.8	−14	−86	−8
	Calcarine_L	13.9	−12	−90	−6
	Frontal_Inf_Oper_L	29.2	−40	4	26

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Intermittent Theta Burst Stimulation (iTBS) for Treatment of Chronic Post-Stroke Aphasia: Results of a Pilot Randomized, Double-Blind, Sham-Controlled Trial

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