Knockout of the Cannabinoid Receptor 2 Gene Promotes Inflammation and Hepatic Stellate Cell Activation by Promoting A20/Nuclear Factor-κB (NF-κB) Expression in Mice with Carbon Tetrachloride-Induced Liver Fibrosis

Cuizhen Long; Na Xie; Yuanhui Shu; Yafeng Wu; Ping He; Yan Zhou; Yining Xiang; Junying Gu; Lei Yang; Yuping Wang

doi:10.12659/MSM.931236

20 August 2021: Animal Study

Knockout of the Cannabinoid Receptor 2 Gene Promotes Inflammation and Hepatic Stellate Cell Activation by Promoting A20/Nuclear Factor-κB (NF-κB) Expression in Mice with Carbon Tetrachloride-Induced Liver Fibrosis

Cuizhen Long ^123ABCDEF* , Na Xie ^12ABCDEF* , Yuanhui Shu ^12ABCF , Yafeng Wu ^14ABCF , Ping He ^12BC , Yan Zhou ^12BC , Yining Xiang ^5CD , Junying Gu ^12CD , Lei Yang ^12DF , Yuping Wang ^12ABCDEFG*

DOI: 10.12659/MSM.931236

Med Sci Monit 2021; 27:e931236

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Table 3 Serum ALT and AST level values in 4 groups. Deletion of cannabinoid receptor 2 (CB2) aggravated liver damage. Serum ALT and AST level values are represented the mean±SD.

Groups	n	ALT (U/L)	AST (U/L)
WT control group	6	13±1.41	66.33±7.41
WT model group	6	44.67±1.89^#	118.67±11.73^#
CB2−/− control group	6	13.33±0.47	65.00±7.79
CB2−/− model group	6	159.67±20.68^*	372.00±9.80^*
ALT – alanine aminotransferase; AST – aspartate aminotransferase. ^# ^* ^&

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Knockout of the Cannabinoid Receptor 2 Gene Promotes Inflammation and Hepatic Stellate Cell Activation by Promoting A20/Nuclear Factor-κB (NF-κB) Expression in Mice with Carbon Tetrachloride-Induced Liver Fibrosis

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