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19 March 2021: Clinical Research

Association Between Body Mass Index and Thyroid Function in Euthyroid Chinese Adults

Jing Fu 1ACE , Lin Zhang 1BDF , Yu An 1C , Yan Duan 1B , Jia Liu 1ADE* , Guang Wang 12AF*

DOI: 10.12659/MSM.930865

Med Sci Monit 2021; 27:e930865

Table 1 Characteristics of euthyroid Chinese adults with various levels of body weight.

VariablesNormal weight group (BMI 18.5–23.9) (n=625)Overweight group (BMI 24.0–27.9) (n=776)Obesity group (BMI ≥28) (n=163)p for trend
Age, y47.18±12.6846.97±9.0346.40±10.870.717
Gender, Males/Females, n430/195550/226116/470.665
BMI22.77±1.6527.01±1.34** 32.07±1.98**
Waist circumference, cm81.18±6.9992.59±6.45** 103.23±6.33**
TSH, mIU/L1.47 (1.12–2.06)1.54 (1.13–2.04)1.63 (1.27–2.12)0.127
FT3, pmol/L5.28±0.545.36±0.56* 5.46±0.52**
FT4, pmol/L16.44±1.9916.35±2.0916.14±1.880.235
FT3/FT40.32±0.040.33±0.04** 0.34±0.04**
TG-Ab, U/mL15.40 (15.00–22.15)15.70 (15.00–22.20)15.10 (15.00–22.40)0.877
TPO-Ab, U/mL28.00 (28.00–36.80)30.35 (28.00–39.28)* 30.60 (28.00–39.30)* 0.004
TC, mmol/L4.96±0.915.14±0.95** 5.21±0.93**
LDL-C, mmol/L2.69±0.702.85±0.77** 2.94±0.75**
HDL-C, mmol/L1.28±0.311.15±0.27** 1.08±0.25**
TG, mmol/L1.19 (0.82–1.70)1.57 (1.08–2.25)** 1.85 (1.34–2.72)**
FBG, mmol/L5.42±0.525.60±0.54** 5.67±0.56**
FINS, uIU/mL7.73 (5.59–11.29)12.1 (8.71–16.58)** 17.17 (13.69–23.09)**
HOMA-IR1.90 (1.33–2.69)3.02 (2.14–4.16)** 4.24 (3.33–5.86)**
HOMA-β84.56 (58.49–116.90)114.76 (85.82–163.61)** 170.52 (125.61–234.71)**
WBC, 10/L6.17±1.636.52±1.66** 7.05±1.79**
Neutrophils, 10/L3.53±1.223.72±1.26* 4.07±1.37**
Lymphocyte, 10/L2.11±0.602.24±0.63** 2.40±0.63**
Platelet, 10/L216.95±48.17222.57±49.88* 226.48±55.60* 0.038
NLR1.75±0.671.75±0.671.77±0.660.903
BMI – body mass index; TSH – serum thyrotropin; FT3 – free triiodothyronine; FT4 – free thyroxine; TgAb – anti-thyroglobulin antibody; TPOab – antithyroid peroxidase antibody; TC – total cholesterol; LDL-C – low-density lipoprotein cholesterol; HDL-C – high-density lipoprotein cholesterol; TG – triglyceride; FBG – fasting blood glucose; FINS – fasting serum insulin; HOMA-IR – homeostasis model assessment of insulin resistance; HOMA-β – homeostasis model assessment of β-cell function; WBC – white blood cell; NLR – neutrophil-to-lymphocyte ratio. Compared with the normal weight group,
* significantly different at
** significantly different at
Comparing with the overweight group,
# significantly different at
## significantly different at

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750