19 March 2021>: Clinical Research
Association Between Body Mass Index and Thyroid Function in Euthyroid Chinese Adults
Jing Fu 1ACE , Lin Zhang 1BDF , Yu An 1C , Yan Duan 1B , Jia Liu 1ADE* , Guang Wang 12AF*DOI: 10.12659/MSM.930865
Med Sci Monit 2021; 27:e930865
Table 1 Characteristics of euthyroid Chinese adults with various levels of body weight.
Variables | Normal weight group (BMI 18.5–23.9) (n=625) | Overweight group (BMI 24.0–27.9) (n=776) | Obesity group (BMI ≥28) (n=163) | p for trend |
---|---|---|---|---|
Age, y | 47.18±12.68 | 46.97±9.03 | 46.40±10.87 | 0.717 |
Gender, Males/Females, n | 430/195 | 550/226 | 116/47 | 0.665 |
BMI | 22.77±1.65 | 27.01±1.34** | 32.07±1.98** | |
Waist circumference, cm | 81.18±6.99 | 92.59±6.45** | 103.23±6.33** | |
TSH, mIU/L | 1.47 (1.12–2.06) | 1.54 (1.13–2.04) | 1.63 (1.27–2.12) | 0.127 |
FT3, pmol/L | 5.28±0.54 | 5.36±0.56* | 5.46±0.52** | |
FT4, pmol/L | 16.44±1.99 | 16.35±2.09 | 16.14±1.88 | 0.235 |
FT3/FT4 | 0.32±0.04 | 0.33±0.04** | 0.34±0.04** | |
TG-Ab, U/mL | 15.40 (15.00–22.15) | 15.70 (15.00–22.20) | 15.10 (15.00–22.40) | 0.877 |
TPO-Ab, U/mL | 28.00 (28.00–36.80) | 30.35 (28.00–39.28)* | 30.60 (28.00–39.30)* | 0.004 |
TC, mmol/L | 4.96±0.91 | 5.14±0.95** | 5.21±0.93** | |
LDL-C, mmol/L | 2.69±0.70 | 2.85±0.77** | 2.94±0.75** | |
HDL-C, mmol/L | 1.28±0.31 | 1.15±0.27** | 1.08±0.25** | |
TG, mmol/L | 1.19 (0.82–1.70) | 1.57 (1.08–2.25)** | 1.85 (1.34–2.72)** | |
FBG, mmol/L | 5.42±0.52 | 5.60±0.54** | 5.67±0.56** | |
FINS, uIU/mL | 7.73 (5.59–11.29) | 12.1 (8.71–16.58)** | 17.17 (13.69–23.09)** | |
HOMA-IR | 1.90 (1.33–2.69) | 3.02 (2.14–4.16)** | 4.24 (3.33–5.86)** | |
HOMA-β | 84.56 (58.49–116.90) | 114.76 (85.82–163.61)** | 170.52 (125.61–234.71)** | |
WBC, 10/L | 6.17±1.63 | 6.52±1.66** | 7.05±1.79** | |
Neutrophils, 10/L | 3.53±1.22 | 3.72±1.26* | 4.07±1.37** | |
Lymphocyte, 10/L | 2.11±0.60 | 2.24±0.63** | 2.40±0.63** | |
Platelet, 10/L | 216.95±48.17 | 222.57±49.88* | 226.48±55.60* | 0.038 |
NLR | 1.75±0.67 | 1.75±0.67 | 1.77±0.66 | 0.903 |
BMI – body mass index; TSH – serum thyrotropin; FT3 – free triiodothyronine; FT4 – free thyroxine; TgAb – anti-thyroglobulin antibody; TPOab – antithyroid peroxidase antibody; TC – total cholesterol; LDL-C – low-density lipoprotein cholesterol; HDL-C – high-density lipoprotein cholesterol; TG – triglyceride; FBG – fasting blood glucose; FINS – fasting serum insulin; HOMA-IR – homeostasis model assessment of insulin resistance; HOMA-β – homeostasis model assessment of β-cell function; WBC – white blood cell; NLR – neutrophil-to-lymphocyte ratio. Compared with the normal weight group, * significantly different at ** significantly different at Comparing with the overweight group, # significantly different at ## significantly different at |